J. Alan Diehl
J. Alan Diehl
Chair, Department of Biochemistry, Case Western Reserve University
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Glycogen synthase kinase-3β regulates cyclin D1 proteolysis and subcellular localization
JA Diehl, M Cheng, MF Roussel, CJ Sherr
Genes & development 12 (22), 3499-3511, 1998
The p21Cip1 and p27Kip1 CDK ‘inhibitors’ are essential activators of cyclin D‐dependent kinases in murine fibroblasts
M Cheng, P Olivier, JA Diehl, M Fero, MF Roussel, JM Roberts, CJ Sherr
The EMBO journal, 1999
Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival
SB Cullinan, D Zhang, M Hannink, E Arvisais, RJ Kaufman, JA Diehl
Molecular and cellular biology 23 (20), 7198-7209, 2003
The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: oxidative stress sensing by a Cul3-Keap1 ligase
SB Cullinan, JD Gordan, J Jin, JW Harper, JA Diehl
Molecular and cellular biology 24 (19), 8477-8486, 2004
Inhibition of cyclin D1 phosphorylation on threonine-286 prevents its rapid degradation via the ubiquitin-proteasome pathway.
JA Diehl, F Zindy, CJ Sherr
Genes & development 11 (8), 957-972, 1997
HIF-2α promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity
JD Gordan, JA Bertout, CJ Hu, JA Diehl, MC Simon
Cancer cell 11 (4), 335-347, 2007
Two distinct stress signaling pathways converge upon the CHOP promoter during the mammalian unfolded protein response
Y Ma, JW Brewer, JA Diehl, LM Hendershot
Journal of molecular biology 318 (5), 1351-1365, 2002
PERK-dependent activation of Nrf2 contributes to redox homeostasis and cell survival following endoplasmic reticulum stress
SB Cullinan, JA Diehl
Journal of Biological Chemistry 279 (19), 20108-20117, 2004
The GCN2‐ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation
J Ye, M Kumanova, LS Hart, K Sloane, H Zhang, DN De Panis, ...
The EMBO journal 29 (12), 2082-2096, 2010
Coordination of ER and oxidative stress signaling: the PERK/Nrf2 signaling pathway
SB Cullinan, JA Diehl
The international journal of biochemistry & cell biology 38 (3), 317-332, 2006
Phosphorylation-dependent regulation of cyclin D1 nuclear export and cyclin D1–dependent cellular transformation
JR Alt, JL Cleveland, M Hannink, JA Diehl
Genes & development 14 (24), 3102-3114, 2000
The role of the PERK/eIF2α/ATF4/CHOP signaling pathway in tumor progression during endoplasmic reticulum stress
W Rozpedek, D Pytel, B Mucha, H Leszczynska, JA Diehl, I Majsterek
Current molecular medicine 16 (6), 533-544, 2016
Cycling to cancer with cyclin D1
JA Diehl
Cancer biology & therapy 1 (3), 226-231, 2002
Cyclin D1, cancer progression, and opportunities in cancer treatment
S Qie, JA Diehl
Journal of molecular medicine 94, 1313-1326, 2016
PERK mediates cell-cycle exit during the mammalian unfolded protein response
JW Brewer, JA Diehl
Proceedings of the National Academy of Sciences 97 (23), 12625-12630, 2000
Nuclear cyclin D1: an oncogenic driver in human cancer
JK Kim, JA Diehl
Journal of cellular physiology 220 (2), 292-296, 2009
Cyclin D1: polymorphism, aberrant splicing and cancer risk
KE Knudsen, JA Diehl, CA Haiman, ES Knudsen
Oncogene 25 (11), 1620-1628, 2006
Phosphorylation-dependent ubiquitination of cyclin D1 by the SCFFBX4-αB crystallin complex
DI Lin, O Barbash, KGS Kumar, JD Weber, JW Harper, AJP Klein-Szanto, ...
Molecular cell 24 (3), 355-366, 2006
ER stress–mediated autophagy promotes Myc-dependent transformation and tumor growth
LS Hart, JT Cunningham, T Datta, S Dey, F Tameire, SL Lehman, BO Qiu, ...
The Journal of clinical investigation 122 (12), 4621-4634, 2012
Mammalian unfolded protein response inhibits cyclin D1 translation and cell-cycle progression
JW Brewer, LM Hendershot, CJ Sherr, JA Diehl
Proceedings of the National Academy of Sciences 96 (15), 8505-8510, 1999
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