Giuseppe Melacini
Giuseppe Melacini
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Acetyl-terminated and template-assembled collagen-based polypeptides composed of Gly-Pro-Hyp sequences. 2. Synthesis and conformational analysis by circular dichroism …
Y Feng, G Melacini, JP Taulane, M Goodman
Journal of the American Chemical Society 118 (43), 10351-10358, 1996
Mapping allostery through the covariance analysis of NMR chemical shifts
R Selvaratnam, S Chowdhury, B VanSchouwen, G Melacini
Proceedings of the National Academy of Sciences 108 (15), 6133-6138, 2011
cAMP activation of PKA defines an ancient signaling mechanism
R Das, V Esposito, M Abu-Abed, GS Anand, SS Taylor, G Melacini
Proceedings of the National Academy of Sciences 104 (1), 93-98, 2007
Orientation and effects of mastoparan X on phospholipid bicelles
JA Whiles, R Brasseur, KJ Glover, G Melacini, EA Komives, RR Vold
Biophysical Journal 80 (1), 280-293, 2001
Chemical genomics in Escherichia coli identifies an inhibitor of bacterial lipoprotein targeting
R Pathania, S Zlitni, C Barker, R Das, DA Gerritsma, J Lebert, E Awuah, ...
Nature chemical biology 5 (11), 849-856, 2009
Multiconformational NMR Analysis of Sandostatin (Octreotide):  Equilibrium between β-Sheet and Partially Helical Structures,
G Melacini, Q Zhu, M Goodman
Biochemistry 36 (6), 1233-1241, 1997
Hydration dynamics of the collagen triple helix by NMR
G Melacini, AMJJ Bonvin, M Goodman, R Boelens, R Kaptein
Journal of Molecular Biology 300 (5), 1041-1048, 2000
Understanding the molecular basis for the inhibition of the Alzheimer's Aβ-peptide oligomerization by human serum albumin using saturation transfer difference and off-resonance …
J Milojevic, V Esposito, R Das, G Melacini
Journal of the American Chemical Society 129 (14), 4282-4290, 2007
Lanthionine− somatostatin analogs: synthesis, characterization, biological activity, and enzymatic stability studies
G Ösapay, L Prokai, HS Kim, KF Medzihradszky, DH Coy, G Liapakis, ...
Journal of medicinal chemistry 40 (14), 2241-2251, 1997
A template-induced incipient collagen-like triple-helical structure
M Goodman, Y Feng, G Melacini, JP Taulane
Journal of the American Chemical Society 118 (21), 5156-5157, 1996
Biochemical and pharmacological characterizations of ESI-09 based EPAC inhibitors: defining the ESI-09 “therapeutic window”
Y Zhu, H Chen, S Boulton, F Mei, N Ye, G Melacini, J Zhou, X Cheng
Scientific reports 5 (1), 9344, 2015
Signaling through dynamic linkers as revealed by PKA
M Akimoto, R Selvaratnam, ET McNicholl, G Verma, SS Taylor, G Melacini
Proceedings of the National Academy of Sciences 110 (35), 14231-14236, 2013
Stoichiometry and affinity of the human serum albumin-Alzheimer's Aβ peptide interactions
J Milojevic, G Melacini
Biophysical journal 100 (1), 183-192, 2011
Human serum albumin inhibits Aβ fibrillization through a “monomer-competitor” mechanism
J Milojevic, A Raditsis, G Melacini
Biophysical journal 97 (9), 2585-2594, 2009
The solution structure of Lac repressor headpiece 62 complexed to a symmetrical lac operator
CAEM Spronk, AMJJ Bonvin, PK Radha, G Melacini, R Boelens, ...
Structure 7 (12), S1-S3, 1999
The projection analysis of NMR chemical shifts reveals extended EPAC autoinhibition determinants
R Selvaratnam, B VanSchouwen, F Fogolari, MT Mazhab-Jafari, R Das, ...
Biophysical journal 102 (3), 630-639, 2012
A mechanism for the auto-inhibition of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel opening and its relief by cAMP
M Akimoto, Z Zhang, S Boulton, R Selvaratnam, B VanSchouwen, ...
Journal of Biological Chemistry 289 (32), 22205-22220, 2014
A refined model for the somatostatin pharmacophore: conformational analysis of lanthionine− sandostatin analogs
G Melacini, Q Zhu, G Ösapay, M Goodman
Journal of medicinal chemistry 40 (14), 2252-2258, 1997
Collagen‐based structures containing the peptoid residue N‐isobutylglycine (Nleu): Synthesis and biophysical studies of Gly‐Pro‐Nleu sequences by circular dichroism …
Y Feng, G Melacini, JP Taulane, M Goodman
Biopolymers 39 (6), 859-872, 1996
Dynamically driven ligand selectivity in cyclic nucleotide binding domains
R Das, S Chowdhury, MT Mazhab-Jafari, S SilDas, R Selvaratnam, ...
Journal of Biological Chemistry 284 (35), 23682-23696, 2009
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