Acetyl-terminated and template-assembled collagen-based polypeptides composed of Gly-Pro-Hyp sequences. 2. Synthesis and conformational analysis by circular dichroism … Y Feng, G Melacini, JP Taulane, M Goodman Journal of the American Chemical Society 118 (43), 10351-10358, 1996 | 262 | 1996 |
Mapping allostery through the covariance analysis of NMR chemical shifts R Selvaratnam, S Chowdhury, B VanSchouwen, G Melacini Proceedings of the National Academy of Sciences 108 (15), 6133-6138, 2011 | 248 | 2011 |
cAMP activation of PKA defines an ancient signaling mechanism R Das, V Esposito, M Abu-Abed, GS Anand, SS Taylor, G Melacini Proceedings of the National Academy of Sciences 104 (1), 93-98, 2007 | 160 | 2007 |
Chemical genomics in Escherichia coli identifies an inhibitor of bacterial lipoprotein targeting R Pathania, S Zlitni, C Barker, R Das, DA Gerritsma, J Lebert, E Awuah, ... Nature chemical biology 5 (11), 849-856, 2009 | 142 | 2009 |
Orientation and effects of mastoparan X on phospholipid bicelles JA Whiles, R Brasseur, KJ Glover, G Melacini, EA Komives, RR Vold Biophysical Journal 80 (1), 280-293, 2001 | 141 | 2001 |
Understanding the molecular basis for the inhibition of the Alzheimer's Aβ-peptide oligomerization by human serum albumin using saturation transfer difference and off-resonance … J Milojevic, V Esposito, R Das, G Melacini Journal of the American Chemical Society 129 (14), 4282-4290, 2007 | 139 | 2007 |
Multiconformational NMR Analysis of Sandostatin (Octreotide): Equilibrium between β-Sheet and Partially Helical Structures, G Melacini, Q Zhu, M Goodman Biochemistry 36 (6), 1233-1241, 1997 | 136 | 1997 |
Hydration dynamics of the collagen triple helix by NMR G Melacini, AMJJ Bonvin, M Goodman, R Boelens, R Kaptein Journal of molecular biology 300 (5), 1041-1048, 2000 | 135 | 2000 |
Lanthionine− somatostatin analogs: synthesis, characterization, biological activity, and enzymatic stability studies G Ösapay, L Prokai, HS Kim, KF Medzihradszky, DH Coy, G Liapakis, ... Journal of medicinal chemistry 40 (14), 2241-2251, 1997 | 129 | 1997 |
A template-induced incipient collagen-like triple-helical structure M Goodman, Y Feng, G Melacini, JP Taulane Journal of the American Chemical Society 118 (21), 5156-5157, 1996 | 129 | 1996 |
Biochemical and pharmacological characterizations of ESI-09 based EPAC inhibitors: defining the ESI-09 “therapeutic window” Y Zhu, H Chen, S Boulton, F Mei, N Ye, G Melacini, J Zhou, X Cheng Scientific reports 5 (1), 9344, 2015 | 124 | 2015 |
Signaling through dynamic linkers as revealed by PKA M Akimoto, R Selvaratnam, ET McNicholl, G Verma, SS Taylor, G Melacini Proceedings of the National Academy of Sciences 110 (35), 14231-14236, 2013 | 121 | 2013 |
Human serum albumin inhibits Aβ fibrillization through a “monomer-competitor” mechanism J Milojevic, A Raditsis, G Melacini Biophysical journal 97 (9), 2585-2594, 2009 | 116 | 2009 |
Stoichiometry and affinity of the human serum albumin-Alzheimer's Aβ peptide interactions J Milojevic, G Melacini Biophysical journal 100 (1), 183-192, 2011 | 114 | 2011 |
The solution structure of Lac repressor headpiece 62 complexed to a symmetrical lac operator CAEM Spronk, AMJJ Bonvin, PK Radha, G Melacini, R Boelens, ... Structure 7 (12), 1483-1492, 1999 | 103 | 1999 |
Molecular mechanism for the (−)-epigallocatechin gallate-induced toxic to nontoxic remodeling of Aβ oligomers R Ahmed, B VanSchouwen, N Jafari, X Ni, J Ortega, G Melacini Journal of the American Chemical Society 139 (39), 13720-13734, 2017 | 97 | 2017 |
The projection analysis of NMR chemical shifts reveals extended EPAC autoinhibition determinants R Selvaratnam, B VanSchouwen, F Fogolari, MT Mazhab-Jafari, R Das, ... Biophysical journal 102 (3), 630-639, 2012 | 96 | 2012 |
A mechanism for the auto-inhibition of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel opening and its relief by cAMP M Akimoto, Z Zhang, S Boulton, R Selvaratnam, B VanSchouwen, ... Journal of Biological Chemistry 289 (32), 22205-22220, 2014 | 95 | 2014 |
Dynamically driven ligand selectivity in cyclic nucleotide binding domains R Das, S Chowdhury, MT Mazhab-Jafari, S SilDas, R Selvaratnam, ... Journal of Biological Chemistry 284 (35), 23682-23696, 2009 | 91 | 2009 |
A refined model for the somatostatin pharmacophore: conformational analysis of lanthionine− sandostatin analogs G Melacini, Q Zhu, G Ösapay, M Goodman Journal of medicinal chemistry 40 (14), 2252-2258, 1997 | 90 | 1997 |