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Mitchell R. McGill, PhD, NRCC(CC)
Mitchell R. McGill, PhD, NRCC(CC)
Associate Professor at UAMS
Dirección de correo verificada de uams.edu - Página principal
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The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation
MR McGill, MR Sharpe, CD Williams, M Taha, SC Curry, H Jaeschke
The Journal of clinical investigation 122 (4), 1574-1583, 2012
8332012
Metabolism and disposition of acetaminophen: recent advances in relation to hepatotoxicity and diagnosis
MR McGill, H Jaeschke
Pharmaceutical research 30, 2174-2187, 2013
6712013
Acetaminophen-induced liver injury in rats and mice: comparison of protein adducts, mitochondrial dysfunction, and oxidative stress in the mechanism of toxicity
MR McGill, CD Williams, Y Xie, A Ramachandran, H Jaeschke
Toxicology and applied pharmacology 264 (3), 387-394, 2012
4512012
The past and present of serum aminotransferases and the future of liver injury biomarkers
MR McGill
EXCLI journal 15, 817, 2016
4452016
HepaRG cells: a human model to study mechanisms of acetaminophen hepatotoxicity
MR McGill, HM Yan, A Ramachandran, GJ Murray, DE Rollins, ...
Hepatology 53 (3), 974-982, 2011
3252011
Receptor interacting protein kinase 3 is a critical early mediator of acetaminophen‐induced hepatocyte necrosis in mice
A Ramachandran, MR McGill, Y Xie, HM Ni, WX Ding, H Jaeschke
Hepatology 58 (6), 2099-2108, 2013
2742013
Current issues with acetaminophen hepatotoxicity—a clinically relevant model to test the efficacy of natural products
H Jaeschke, MR McGill, CD Williams, A Ramachandran
Life sciences 88 (17-18), 737-745, 2011
2672011
Acetaminophen-induced liver injury: from animal models to humans
H Jaeschke, Y Xie, MR McGill
Journal of clinical and translational hepatology 2 (3), 153, 2014
2452014
Mechanisms of acetaminophen-induced cell death in primary human hepatocytes
Y Xie, MR McGill, K Dorko, SC Kumer, TM Schmitt, J Forster, H Jaeschke
Toxicology and applied pharmacology 279 (3), 266-274, 2014
2372014
Plasma and liver acetaminophen-protein adduct levels in mice after acetaminophen treatment: Dose–response, mechanisms, and clinical implications
MR McGill, M Lebofsky, HRK Norris, MH Slawson, ML Bajt, Y Xie, ...
Toxicology and applied pharmacology 269 (3), 240-249, 2013
2342013
Removal of acetaminophen protein adducts by autophagy protects against acetaminophen-induced liver injury in mice
HM Ni, MR McGill, X Chao, K Du, JA Williams, Y Xie, H Jaeschke, ...
Journal of hepatology 65 (2), 354-362, 2016
1972016
Circulating microRNA profiles in human patients with acetaminophen hepatotoxicity or ischemic hepatitis
J Ward, C Kanchagar, I Veksler-Lublinsky, RC Lee, MR McGill, ...
Proceedings of the National Academy of Sciences 111 (33), 12169-12174, 2014
1882014
Models of drug-induced liver injury for evaluation of phytotherapeutics and other natural products
H Jaeschke, CD Williams, MR McGill, Y Xie, A Ramachandran
Food and Chemical Toxicology 55, 279-289, 2013
1712013
Liver-specific loss of Atg5 causes persistent activation of Nrf2 and protects against acetaminophen-induced liver injury
HM Ni, N Boggess, MR McGill, M Lebofsky, P Borude, U Apte, H Jaeschke, ...
Toxicological Sciences 127 (2), 438-450, 2012
1682012
Neutrophil activation during acetaminophen hepatotoxicity and repair in mice and humans
CD Williams, ML Bajt, MR Sharpe, MR McGill, A Farhood, H Jaeschke
Toxicology and applied pharmacology 275 (2), 122-133, 2014
1662014
Serum mitochondrial biomarkers and damage‐associated molecular patterns are higher in acetaminophen overdose patients with poor outcome
MR McGill, VS Staggs, MR Sharpe, WM Lee, H Jaeschke, ...
Hepatology 60 (4), 1336-1345, 2014
1432014
Animal models of drug-induced liver injury
MR McGill, H Jaeschke
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1865 (5 …, 2019
1392019
Circulating acylcarnitines as biomarkers of mitochondrial dysfunction after acetaminophen overdose in mice and humans
MR McGill, F Li, MR Sharpe, CD Williams, SC Curry, X Ma, H Jaeschke
Archives of toxicology 88, 391-401, 2014
1372014
Hepatotoxicity of a cannabidiol-rich cannabis extract in the mouse model
LE Ewing, CM Skinner, CM Quick, S Kennon-McGill, MR McGill, ...
Molecules 24 (9), 1694, 2019
1252019
Mechanistic biomarkers in acetaminophen-induced hepatotoxicity and acute liver failure: from preclinical models to patients
MR McGill, H Jaeschke
Expert opinion on drug metabolism & toxicology 10 (7), 1005-1017, 2014
1172014
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