William Stephen Brimijoin
William Stephen Brimijoin
Professor of Pharmacology, Mayo Clinic, Mayo Graduate School
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Highly potent, selective, and low cost bis-tetrahydroaminacrine inhibitors of acetylcholinesterase: steps toward novel drugs for treating Alzheimer's disease
YP Pang, P Quiram, T Jelacic, F Hong, S Brimijoin
Journal of Biological Chemistry 271 (39), 23646-23649, 1996
Abundant tissue butyrylcholinesterase and its possible function in the acetylcholinesterase knockout mouse
B Li, JA Stribley, A Ticu, W Xie, LM Schopfer, P Hammond, S Brimijoin, ...
Journal of neurochemistry 75 (3), 1320-1331, 2000
Axonal transport of substance P in the vagus and sciatic nerves of the guinea pig
S Brimijoin, JM Lundberg, E Brodin, T Ho
Brain Research 191 (2), 443-457, 1980
Acetylcholinesterase promotes beta-amyloid plaques in cerebral cortex
T Rees, PI Hammond, H Soreq, S Younkin, S Brimijoin
Neurobiology of aging 24 (6), 777-787, 2003
Molecular forms of acetylcholinesterase in brain, nerve and muscle: nature, localization and dynamics
S Brimijoin
Progress in neurobiology 21 (4), 291-322, 1983
Neurally mediated increase in dopamine-β-hydroxylase activity
PB Molinoff, S Brimijoin, R Weinshilboum, J Axelrod
Proceedings of the National Academy of Sciences 66 (2), 453-458, 1970
1, 25-Dihydroxyvitamin D3 receptors in the central nervous system of the rat embryo
TD Veenstra, K Prüfer, C Koenigsberger, SW Brimijoin, JP Grande, ...
Brain research 804 (2), 193-205, 1998
Retrograde axonal transport of transmitter enzymes, fucose-labeled protein, and nerve growth factor in streptozotocin-diabetic rats
J Jakobsen, S Brimijoin, K Skau, P Sidenius, D Wells
Diabetes 30 (10), 797-803, 1981
Re-engineering butyrylcholinesterase as a cocaine hydrolase
H Sun, YP Pang, O Lockridge, S Brimijoin
Molecular pharmacology 62 (2), 220-224, 2002
Peripheral peptide neurons: distribution, axonal transport, and some aspects on possible function
JM Lundberg, T Hökfelt, A Anggård, K Uvnäs-Wallensten, S Brimijoin, ...
Advances in biochemical psychopharmacology 22, 25-36, 1980
A cocaine hydrolase engineered from human butyrylcholinesterase selectively blocks cocaine toxicity and reinstatement of drug seeking in rats
S Brimijoin, Y Gao, JJ Anker, LA Gliddon, D LaFleur, R Shah, Q Zhao, ...
Neuropsychopharmacology 33 (11), 2715-2725, 2008
The role of acetylcholinesterase in the pathogenesis of Alzheimer's disease.
TM Rees, S Brimijoin
Drugs of today (Barcelona, Spain: 1998) 39 (1), 75-83, 2003
Neurite differentiation is modulated in neuroblastoma cells engineered for altered acetylcholinesterase expression
C Koenigsberger, S Chiappa, S Brimijoin
Journal of neurochemistry 69 (4), 1389-1397, 1997
Cholinesterases in neural development: new findings and toxicologic implications.
S Brimijoin, C Koenigsberger
Environmental health perspectives 107 (suppl 1), 59-64, 1999
Ischemic conduction failure and energy metabolism in experimental diabetic neuropathy
PA Low, K Ward, JD Schmelzer, S Brimijoin
American Journal of Physiology-Endocrinology and Metabolism 248 (4), E457-E462, 1985
Rational design of alkylene-linked bis-pyridiniumaldoximes as improved acetylcholinesterase reactivators
YP Pang, TM Kollmeyer, F Hong, JC Lee, PI Hammond, SP Haugabouk, ...
Chemistry & biology 10 (6), 491-502, 2003
Cholinesterases and the fine line between poison and remedy
CN Pope, S Brimijoin
Biochemical pharmacology 153, 205-216, 2018
Plasma butyrylcholinesterase regulates ghrelin to control aggression
VP Chen, Y Gao, L Geng, RJ Parks, YP Pang, S Brimijoin
Proceedings of the National Academy of Sciences 112 (7), 2251-2256, 2015
Direct evidence for an adhesive function in the noncholinergic role of acetylcholinesterase in neurite outgrowth
KV Sharma, C Koenigsberger, S Brimijoin, JW Bigbee
Journal of neuroscience research 63 (2), 165-175, 2001
Comparison of thein VitroSensitivity of rat acetylcholinesterase to chlorpyrifos-oxon: What do tissue IC50 values represent?
SR Mortensen, S Brimijoin, MJ Hooper, S Padilla
Toxicology and applied pharmacology 148 (1), 46-49, 1998
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