Wayland Yeung
Wayland Yeung
Tessera Therapeutics
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Tracing the origin and evolution of pseudokinases across the tree of life
A Kwon, S Scott, R Taujale, W Yeung, KJ Kochut, PA Eyers, N Kannan
Sci. Signal. 12 (578), eaav3810, 2019
Covalent inhibitors of EGFR family protein kinases induce degradation of human Tribbles 2 (TRIB2) pseudokinase in cancer cells
DM Foulkes, DP Byrne, W Yeung, S Shrestha, FP Bailey, S Ferries, ...
Sci. Signal. 11 (549), eaat7951, 2018
mTORC2 controls the activity of PKC and Akt by phosphorylating a conserved TOR interaction motif
TR Baffi, G Lordén, JM Wozniak, A Feichtner, W Yeung, AP Kornev, ...
Science signaling 14 (678), eabe4509, 2021
In vitro selection of diversely functionalized aptamers
D Kong, W Yeung, R Hili
Journal of the American Chemical Society 139 (40), 13977-13980, 2017
Deep evolutionary analysis reveals the design principles of fold A glycosyltransferases
R Taujale, A Venkat, LC Huang, Z Zhou, W Yeung, K Rasheed, S Li, ...
Elife, 2020
Conformational interconversion of MLKL and disengagement from RIPK3 precede cell death by necroptosis
SE Garnish, Y Meng, A Koide, JJ Sandow, E Denbaum, AV Jacobsen, ...
Nature communications 12 (1), 2211, 2021
Distinct pseudokinase domain conformations underlie divergent activation mechanisms among vertebrate MLKL orthologues
KA Davies, C Fitzgibbon, SN Young, SE Garnish, W Yeung, D Coursier, ...
Nature Communications 11 (1), 3060, 2020
Mapping the glycosyltransferase fold landscape using interpretable deep learning
R Taujale, Z Zhou, W Yeung, KW Moremen, S Li, N Kannan
Nature communications 12 (1), 5656, 2021
The crystal structure of the protein kinase HIPK2 reveals a unique architecture of its CMGC-insert region
C Agnew, L Liu, S Liu, W Xu, L You, W Yeung, N Kannan, D Jablons, ...
Journal of Biological Chemistry 294 (37), 13545-13559, 2019
Enzymatic Synthesis of Sequence‐Defined Synthetic Nucleic Acid Polymers with Diverse Functional Groups
D Kong, Y Lei, W Yeung, R Hili
Angewandte Chemie International Edition 55 (42), 13164-13168, 2016
Emerging roles of the αC‐β4 loop in protein kinase structure, function, evolution, and disease
W Yeung, Z Ruan, N Kannan
IUBMB life 72 (6), 1189-1202, 2020
Lipid-targeting pleckstrin homology domain turns its autoinhibitory face toward the TEC kinases
N Amatya, TE Wales, A Kwon, W Yeung, RE Joseph, DB Fulton, ...
Proceedings of the National Academy of Sciences 116 (43), 21539-21544, 2019
Evolution of functional diversity in the holozoan tyrosine kinome
W Yeung, A Kwon, R Taujale, C Bunn, A Venkat, N Kannan
Molecular biology and evolution, 2021
Generation of synthetic copolymer libraries by combinatorial assembly on nucleic acid templates
D Kong, W Yeung, R Hili
ACS combinatorial science 18 (7), 355-370, 2016
KinOrtho: a method for mapping human kinase orthologs across the tree of life and illuminating understudied kinases
LC Huang, R Taujale, N Gravel, A Venkat, W Yeung, DP Byrne, PA Eyers, ...
BMC bioinformatics 22, 1-25, 2021
Quantitative Structure–Mutation–Activity Relationship Tests (QSMART) model for protein kinase inhibitor response prediction
LC Huang, W Yeung, Y Wang, H Cheng, A Venkat, S Li, P Ma, K Rasheed, ...
BMC bioinformatics 21, 1-22, 2020
Alignment-free estimation of sequence conservation for identifying functional sites using protein sequence embeddings
W Yeung, Z Zhou, S Li, N Kannan
Briefings in Bioinformatics 24 (1), bbac599, 2023
Phosformer: an explainable transformer model for protein kinase-specific phosphorylation predictions
Z Zhou, W Yeung, N Gravel, M Salcedo, S Soleymani, S Li, N Kannan
Bioinformatics 39 (2), btad046, 2023
Evolutionary Outcomes of Diversely Functionalized Aptamers Isolated from in Vitro Evolution
D Kong, M Movahedi, Y Mahdavi-Amiri, W Yeung, T Tiburcio, D Chen, ...
ACS Synthetic Biology 9 (1), 43-52, 2019
A comprehensive in vivo screen of yeast farnesyltransferase activity reveals broad reactivity across a majority of CXXX sequences
JH Kim, ER Hildebrandt, A Sarkar, W Yeung, LRA Waldon, N Kannan, ...
G3: Genes, Genomes, Genetics 13 (7), jkad094, 2023
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