Drugs and drug-like molecules can modulate the function of mucosal-associated invariant T cells AN Keller, SBG Eckle, W Xu, L Liu, VA Hughes, JYW Mak, BS Meehan, ... Nature immunology 18 (4), 402-411, 2017 | 234 | 2017 |
Diversity of T Cells Restricted by the MHC Class I-Related Molecule MR1 Facilitates Differential Antigen Recognition NA Gherardin, AN Keller, RE Woolley, J Le Nours, DS Ritchie, PJ Neeson, ... Immunity 44 (1), 32-45, 2016 | 212 | 2016 |
αβ T cell antigen receptor recognition of CD1a presenting self lipid ligands RW Birkinshaw, DG Pellicci, TY Cheng, AN Keller, M Sandoval-Romero, ... Nature immunology 16 (3), 258-266, 2015 | 150 | 2015 |
Recognition of vitamin B precursors and byproducts by mucosal associated invariant T cells SBG Eckle, AJ Corbett, AN Keller, Z Chen, DI Godfrey, L Liu, JYW Mak, ... Journal of Biological Chemistry 290 (51), 30204-30211, 2015 | 145 | 2015 |
International Union of Basic and Clinical Pharmacology. CVIII. Calcium-Sensing Receptor Nomenclature, Pharmacology, and Function K Leach, FM Hannan, TM Josephs, AN Keller, TC Mřller, DT Ward, ... Pharmacological Reviews 72 (3), 558-604, 2020 | 94 | 2020 |
MAIT cells and MR1-antigen recognition AN Keller, AJ Corbett, JM Wubben, J McCluskey, J Rossjohn Current Opinion in Immunology 46, 66-74, 2017 | 86 | 2017 |
The molecular basis underpinning the potency and specificity of MAIT cell antigens W Awad, GJM Ler, W Xu, AN Keller, JYW Mak, XY Lim, L Liu, SBG Eckle, ... Nature Immunology 21 (4), 400-411, 2020 | 67 | 2020 |
ε, a new subunit of RNA polymerase found in Gram-positive bacteria AN Keller, X Yang, J Wiedermannová, O Delumeau, L Krásný, PJ Lewis Journal of bacteriology 196 (20), 3622-3632, 2014 | 57 | 2014 |
Dynamics of GLP-1R peptide agonist engagement are correlated with kinetics of G protein activation G Deganutti, YL Liang, X Zhang, M Khoshouei, L Clydesdale, ... Nature communications 13 (1), 1-18, 2022 | 55 | 2022 |
Divergent effects of strontium and calcium‐sensing receptor positive allosteric modulators (calcimimetics) on human osteoclast activity NA Diepenhorst, K Leach, AN Keller, P Rueda, AE Cook, TL Pierce, ... British journal of pharmacology 175 (21), 4095-4108, 2018 | 37 | 2018 |
RNA polymerase-induced remodelling of NusA produces a pause enhancement complex C Ma, M Mobli, X Yang, AN Keller, GF King, PJ Lewis Nucleic acids research 43 (5), 2829-2840, 2015 | 36 | 2015 |
Identification of global and ligand-specific calcium sensing receptor activation mechanisms AN Keller, I Kufareva, TM Josephs, J Diao, VT Mai, AD Conigrave, ... Molecular pharmacology 93 (6), 619-630, 2018 | 27 | 2018 |
Activation of Xer-recombination at dif: structural basis of the FtsKγ–XerD interaction AN Keller, Y Xin, S Boer, J Reinhardt, R Baker, LK Arciszewska, PJ Lewis, ... Scientific reports 6 (1), 1-12, 2016 | 25 | 2016 |
Dual Action Calcium-Sensing Receptor Modulator Unmasks Novel Mode-Switching Mechanism KJ Gregory, I Kufareva, AN Keller, E Khajehali, HC Mun, MA Goolam, ... ACS Pharmacology & Translational Science 1 (2), 96-109, 2018 | 19 | 2018 |
Negative allosteric modulators of the human calcium‐sensing receptor bind to overlapping and distinct sites within the 7‐transmembrane domain TM Josephs, AN Keller, E Khajehali, A DeBono, CJ Langmead, ... British Journal of Pharmacology 177 (8), 1917-1930, 2020 | 18 | 2020 |
Probe dependence and biased potentiation of metabotropic glutamate receptor 5 is mediated by differential ligand interactions in the common allosteric binding site SD Hellyer, K Sengmany, AN Keller, A Christopoulos, K Leach, ... Biochemical pharmacology 177, 114013, 2020 | 12 | 2020 |
Regulation and functional consequences of mGlu4 RNA editing CS Hofmann, S Carrington, AN Keller, KJ Gregory, CM Niswender RNA 27 (10), 1220-1240, 2021 | 6 | 2021 |
Personalised medicines for familial hypercalcemia and hyperparathyroidism TM Josephs, F Zhang, LV Dinh, AN Keller, AD Conigrave, B Capuano, ... Journal of Molecular Endocrinology 69 (1), 243-257, 2022 | 5 | 2022 |
Development of AC265347‐Inspired Calcium‐Sensing Receptor Ago‐Positive Allosteric Modulators LV Dinh, A DeBono, AN Keller, TM Josephs, KJ Gregory, K Leach, ... ChemMedChem 16 (22), 3451-3462, 2021 | 5 | 2021 |
The Calcium‐Sensing Receptor (CaSR) in Disease AN Keller, TM Josephs, KJ Gregory, K Leach GPCRs as Therapeutic Targets 2, 580-630, 2022 | | 2022 |