Differential effects of selective HDAC inhibitors on macrophage inflammatory responses to the Toll-like receptor 4 agonist LPS MA Halili, MR Andrews, LI Labzin, K Schroder, G Matthias, C Cao, ... Journal of leukocyte biology 87 (6), 1103-1114, 2010 | 231 | 2010 |
Conformational selection of inhibitors and substrates by proteolytic enzymes: implications for drug design and polypeptide processing DP Fairlie, JDA Tyndall, RC Reid, AK Wong, G Abbenante, MJ Scanlon, ... Journal of Medicinal Chemistry 43 (7), 1271-1281, 2000 | 221 | 2000 |
A potent human C5a receptor antagonist protects against disease pathology in a rat model of inflammatory bowel disease TM Woodruff, TV Arumugam, IA Shiels, RC Reid, DP Fairlie, SM Taylor The Journal of Immunology 171 (10), 5514-5520, 2003 | 196 | 2003 |
Potencies of Human Immunodeficiency Virus Protease Inhibitors In Vitro against Plasmodium falciparum and In Vivo against Murine Malaria KT Andrews, DP Fairlie, PK Madala, J Ray, DM Wyatt, PM Hilton, ... Antimicrobial agents and chemotherapy 50 (2), 639-648, 2006 | 170 | 2006 |
Antiarthritic activity of an orally active C5a receptor antagonist against antigen‐induced monarticular arthritis in the rat TM Woodruff, AJ Strachan, N Dryburgh, IA Shiels, RC Reid, DP Fairlie, ... Arthritis & rheumatism 46 (9), 2476-2485, 2002 | 163 | 2002 |
C5aR and C3aR antagonists each inhibit diet‐induced obesity, metabolic dysfunction, and adipocyte and macrophage signaling J Lim, A Iyer, JY Suen, V Seow, RC Reid, L Brown, DP Fairlie The FASEB Journal 27 (2), 822-831, 2013 | 159 | 2013 |
Antifibrotic activity of an inhibitor of histone deacetylases in DOCA‐salt hypertensive rats A Iyer, A Fenning, J Lim, GT Le, RC Reid, MA Halili, DP Fairlie, L Brown British journal of pharmacology 159 (7), 1408-1417, 2010 | 158 | 2010 |
Stabilizing short-lived Schiff base derivatives of 5-aminouracils that activate mucosal-associated invariant T cells JYW Mak, W Xu, RC Reid, AJ Corbett, BS Meehan, H Wang, Z Chen, ... Nature communications 8 (1), 14599, 2017 | 149 | 2017 |
Potent cyclic antagonists of the complement C5a receptor on human polymorphonuclear leukocytes. Relationships between structures and activity DR March, LM Proctor, MJ Stoermer, R Sbaglia, G Abbenante, RC Reid, ... Molecular pharmacology 65 (4), 868-879, 2004 | 142 | 2004 |
Protective effect of a new C5a receptor antagonist against ischemia–reperfusion injury in the rat small intestine TV Arumugam, IA Shiels, TM Woodruff, RC Reid, DP Fairlie, SM Taylor Journal of Surgical Research 103 (2), 260-267, 2002 | 142 | 2002 |
Novel agonists and antagonists for human protease activated receptor 2 GD Barry, JY Suen, GT Le, A Cotterell, RC Reid, DP Fairlie Journal of medicinal chemistry 53 (20), 7428-7440, 2010 | 132 | 2010 |
Protective effect of a human C5a receptor antagonist against hepatic ischaemia-reperfusion injury in rats TV Arumugam, TM Woodruff, SZ Stocks, LM Proctor, S Pollitt, IA Shiels, ... Journal of Hepatology 40, 934-941, 2004 | 119 | 2004 |
Inhibitors of secretory phospholipase A2 group IIA RC Reid Current medicinal chemistry 12 (25), 3011-3026, 2005 | 112 | 2005 |
Histone deacetylase 7 promotes Toll-like receptor 4-dependent proinflammatory gene expression in macrophages MR Shakespear, DM Hohenhaus, GM Kelly, NA Kamal, P Gupta, ... Journal of Biological Chemistry 288 (35), 25362-25374, 2013 | 109 | 2013 |
Nonpeptidic ligands for peptide-activated G protein-coupled receptors JS Blakeney, RC Reid, GT Le, DP Fairlie Chemical reviews 107 (7), 2960-3041, 2007 | 107 | 2007 |
D‐Tyrosine as a Chiral Precusor to Potent Inhibitors of Human Nonpancreatic Secretory Phospholipase A2 (IIa) with Antiinflammatory Activity KA Hansford, RC Reid, CI Clark, JDA Tyndall, MW Whitehouse, T Guthrie, ... Chembiochem 4 (2‐3), 181-185, 2003 | 105 | 2003 |
Protective effects of a potent C5a receptor antagonist on experimental acute limb ischemia-reperfusion in rats TM Woodruff, TV Arumugam, IA Shiels, RC Reid, DP Fairlie, SM Taylor Journal of Surgical Research 116 (1), 81-90, 2004 | 103 | 2004 |
Comparative anti‐inflammatory activities of antagonists to C3a and C5a receptors in a rat model of intestinal ischaemia/reperfusion injury LM Proctor, TV Arumugam, I Shiels, RC Reid, DP Fairlie, SM Taylor British journal of pharmacology 142 (4), 756-764, 2004 | 99 | 2004 |
β-Strand mimicking macrocyclic amino acids: templates for protease inhibitors with antiviral activity MP Glenn, LK Pattenden, RC Reid, DP Tyssen, JDA Tyndall, CJ Birch, ... Journal of medicinal chemistry 45 (2), 371-381, 2002 | 94 | 2002 |
Synthesis, stability, antiviral activity, and protease-bound structures of substrate-mimicking constrained macrocyclic inhibitors of HIV-1 protease JDA Tyndall, RC Reid, DP Tyssen, DK Jardine, B Todd, M Passmore, ... Journal of medicinal chemistry 43 (19), 3495-3504, 2000 | 94 | 2000 |