Davide Ruggero
Davide Ruggero
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A SARS-CoV-2 protein interaction map reveals targets for drug repurposing
DE Gordon, GM Jang, M Bouhaddou, J Xu, K Obernier, KM White, ...
Nature 583 (7816), 459-468, 2020
VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche
RN Kaplan, RD Riba, S Zacharoulis, AH Bramley, L Vincent, C Costa, ...
Nature 438 (7069), 820-827, 2005
The translational landscape of mTOR signalling steers cancer initiation and metastasis
AC Hsieh, Y Liu, MP Edlind, NT Ingolia, MR Janes, A Sher, EY Shi, ...
Nature 485 (7396), 55-61, 2012
Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2
ME Feldman, B Apsel, A Uotila, R Loewith, ZA Knight, D Ruggero, ...
PLoS biology 7 (2), e1000038, 2009
Does the ribosome translate cancer?
D Ruggero, PP Pandolfi
Nature Reviews Cancer 3 (3), 179-192, 2003
PML is essential for multiple apoptotic pathways
ZG Wang, D Ruggero, S Ronchetti, S Zhong, M Gaboli, R Rivi, ...
Nature genetics 20 (3), 266-272, 1998
The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis
D Ruggero, L Montanaro, L Ma, W Xu, P Londei, C Cordon-Cardo, ...
Nature medicine 10 (5), 484-486, 2004
IRE1α cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2
JP Upton, L Wang, D Han, ES Wang, NE Huskey, L Lim, M Truitt, ...
Science 338 (6108), 818-822, 2012
Autism-related deficits via dysregulated eIF4E-dependent translational control
CG Gkogkas, A Khoutorsky, I Ran, E Rampakakis, T Nevarko, ...
Nature 493 (7432), 371-377, 2013
Genetic dissection of the oncogenic mTOR pathway reveals druggable addiction to translational control via 4EBP-eIF4E
AC Hsieh, M Costa, O Zollo, C Davis, ME Feldman, JR Testa, O Meyuhas, ...
Cancer cell 17 (3), 249-261, 2010
Dyskeratosis congenita and cancer in mice deficient in ribosomal RNA modification
D Ruggero, S Grisendi, F Piazza, E Rego, F Mari, PH Rao, ...
Science 299 (5604), 259-262, 2003
Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiency
M Barna, A Pusic, O Zollo, M Costa, N Kondrashov, E Rego, PH Rao, ...
Nature 456 (7224), 971-975, 2008
Impaired control of IRES-mediated translation in X-linked dyskeratosis congenita
A Yoon, G Peng, Y Brandenburg, O Zollo, W Xu, E Rego, D Ruggero
Science 312 (5775), 902-906, 2006
ER stress–mediated autophagy promotes Myc-dependent transformation and tumor growth
LS Hart, JT Cunningham, T Datta, S Dey, F Tameire, SL Lehman, BO Qiu, ...
The Journal of clinical investigation 122 (12), 4621-4634, 2012
Targeting the eIF4F translation initiation complex: a critical nexus for cancer development
J Pelletier, J Graff, D Ruggero, N Sonenberg
Cancer research 75 (2), 250-263, 2015
Exaggerated translation causes synaptic and behavioural aberrations associated with autism
E Santini, TN Huynh, AF MacAskill, AG Carter, P Pierre, D Ruggero, ...
Nature 493 (7432), 411-415, 2013
New frontiers in translational control of the cancer genome
ML Truitt, D Ruggero
Nature Reviews Cancer 16 (5), 288-304, 2016
Differential requirements for eIF4E dose in normal development and cancer
ML Truitt, CS Conn, Z Shi, X Pang, T Tokuyasu, AM Coady, Y Seo, ...
Cell 162 (1), 59-71, 2015
Translational control in cancer etiology
D Ruggero
Cold Spring Harbor perspectives in biology 5 (2), a012336, 2013
rRNA pseudouridylation defects affect ribosomal ligand binding and translational fidelity from yeast to human cells
K Jack, C Bellodi, DM Landry, RO Niederer, A Meskauskas, ...
Molecular cell 44 (4), 660-666, 2011
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