Douglas Spitz
Douglas Spitz
Professor of Radiation Oncology, University of Iowa
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A dynamic pathway for calcium-independent activation of CaMKII by methionine oxidation
JR Erickson, AJ Mei-ling, X Guan, W Kutschke, J Yang, CV Oddis, ...
Cell 133 (3), 462-474, 2008
Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress
R Tao, MC Coleman, JD Pennington, O Ozden, SH Park, H Jiang, HS Kim, ...
Molecular cell 40 (6), 893-904, 2010
SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress
HS Kim, K Patel, K Muldoon-Jacobs, KS Bisht, N Aykin-Burns, ...
Cancer cell 17 (1), 41-52, 2010
An assay for superoxide dismutase activity in mammalian tissue homogenates
DR Spitz, LW Oberley
Analytical biochemistry 179 (1), 8-18, 1989
Metabolic oxidation/reduction reactions and cellular responses to ionizing radiation: a unifying concept in stress response biology
DR Spitz, EI Azzam, JJ Li, D Gius
Cancer and Metastasis Reviews 23 (3-4), 311-322, 2004
HSP27 phosphorylation-mediated resistance against actin fragmentation and cell death induced by oxidative stress
J Huot, F Houle, DR Spitz, J Landry
Cancer research 56 (2), 273-279, 1996
[61] assay of superoxide dismutase activity in tumor tissue
LW Oberley, DR Spitz
Methods in enzymology 105, 457-464, 1984
Superoxide mediates the actions of angiotensin II in the central nervous system
MC Zimmerman, E Lazartigues, JA Lang, P Sinnayah, IM Ahmad, ...
Circulation research 91 (11), 1038-1045, 2002
Oxidative metabolism modulates signal transduction and micronucleus formation in bystander cells from α-particle-irradiated normal human fibroblast cultures
EI Azzam, SM De Toledo, DR Spitz, JB Little
Cancer research 62 (19), 5436-5442, 2002
Glucose deprivation‐induced oxidative stress in human tumor cells: a fundamental defect in metabolism?
DR Spitz, JE Sim, LA Ridnour, SS Galoforo, YJ Lee
Annals of the New York Academy of Sciences 899 (1), 349-362, 2000
Increased lipid peroxidation and impaired antioxidant enzyme function is associated with pathological liver injury in experimental alcoholic liver disease in rats fed diets …
R Polavarapu, DR Spitz, JE Sim, MH Follansbee, LW Oberley, ...
Hepatology 27 (5), 1317-1323, 1998
H2O2-induced O⨪ 2production by a non-phagocytic NAD (P) H oxidase causes oxidant injury
WG Li, FJ Miller, HJ Zhang, DR Spitz, LW Oberley, NL Weintraub
Journal of Biological Chemistry 276 (31), 29251-29256, 2001
Increased levels of superoxide and H2O2 mediate the differential susceptibility of cancer cells versus normal cells to glucose deprivation
N Aykin-Burns, IM Ahmad, Y Zhu, LW Oberley, DR Spitz
Biochemical Journal 418 (1), 29-37, 2009
Manganese superoxide dismutase-mediated gene expression in radiation-induced adaptive responses
G Guo, Y Yan-Sanders, BD Lyn-Cook, T Wang, D Tamae, J Ogi, ...
Molecular and cellular biology 23 (7), 2362-2378, 2003
Role of glutaredoxin in metabolic oxidative stress Glutaredoxin as a sensor of oxidative stress mediated by H2O2
JJ Song, JG Rhee, M Suntharalingam, SA Walsh, DR Spitz, YJ Lee
Journal of Biological Chemistry 277 (48), 46566-46575, 2002
Antioxidant effects of N-acetylcysteine and succimer in red blood cells from lead-exposed rats
H Gürer, H Özgünes, R Neal, DR Spitz, N Erçal
Toxicology 128 (3), 181-189, 1998
Glucose deprivation-induced cytotoxicity and alterations in mitogen-activated protein kinase activation are mediated by oxidative stress in multidrug-resistant human breast …
YJ Lee, SS Galoforo, CM Berns, JC Chen, BH Davis, JE Sim, PM Corry, ...
Journal of Biological Chemistry 273 (9), 5294-5299, 1998
Mitochondrial and H2O2 mediate glucose deprivation-induced stress in human cancer cells
IM Ahmad, N Aykin-Burns, JE Sim, SA Walsh, R Higashikubo, ...
Journal of Biological Chemistry 280 (6), 4254-4263, 2005
The role of manganese superoxide dismutase in the growth of pancreatic adenocarcinoma
JJ Cullen, C Weydert, MM Hinkhouse, J Ritchie, FE Domann, D Spitz, ...
Cancer research 63 (6), 1297-1303, 2003
Hydrogen peroxide or heat shock induces resistance to hydrogen peroxide in Chinese hamster fibroblasts
DR Spitz, WC Dewey, GC Li
Journal of cellular physiology 131 (3), 364-373, 1987
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Artículos 1–20