Michael Graham Espey, PhD MT
Michael Graham Espey, PhD MT
Deputy Associate Director, Division of Cancer Diagnosis & Treatment, National Cancer Institute
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A rapid, simple spectrophotometric method for simultaneous detection of nitrate and nitrite
KM Miranda, MG Espey, DA Wink
Nitric Oxide 5 (1), 62-71, 2001
Pharmacologic ascorbic acid concentrations selectively kill cancer cells: action as a pro-drug to deliver hydrogen peroxide to tissues
Q Chen, MG Espey, MC Krishna, JB Mitchell, CP Corpe, GR Buettner, ...
Proceedings of the National Academy of Sciences 102 (38), 13604-13609, 2005
Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice
Q Chen, MG Espey, AY Sun, C Pooput, KL Kirk, MC Krishna, DB Khosh, ...
Proceedings of the National Academy of Sciences 105 (32), 11105-11109, 2008
Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid in vivo
Q Chen, MG Espey, AY Sun, JH Lee, MC Krishna, E Shacter, PL Choyke, ...
Proceedings of the National Academy of Sciences 104 (21), 8749-8754, 2007
The emerging biology of the nitrite anion
MT Gladwin, AN Schechter, DB Kim-Shapiro, RP Patel, N Hogg, S Shiva, ...
Nature Chemical Biology 1 (6), 308-314, 2005
Mechanisms of the antioxidant effects of nitric oxide
DA Wink, KM Miranda, MG Espey, RM Pluta, SJ Hewett, C Colton, M Vitek, ...
Antioxidants and redox signaling 3 (2), 203-213, 2001
The chemistry of nitrosative stress induced by nitric oxide and reactive nitrogen oxide species. Putting perspective on stressful biological situations
LA Ridnour, DD Thomas, D Mancardi, MG Espey, KM Miranda, ...
Walter de Gruyter 385 (1), 1-10, 2004
Nitric oxide-induced cellular stress and p53 activation in chronic inflammation
LJ Hofseth, S Saito, SP Hussain, MG Espey, KM Miranda, Y Araki, ...
Proceedings of the national academy of sciences 100 (1), 143-148, 2003
Vitamin C: intravenous use by complementary and alternative medicine practitioners and adverse effects
SJ Padayatty, AY Sun, Q Chen, MG Espey, J Drisko, M Levine
PloS one 5 (7), e11414, 2010
Vitamin C: a concentration-function approach yields pharmacology and therapeutic discoveries
M Levine, SJ Padayatty, MG Espey
Advances in nutrition 2 (2), 78-88, 2011
Nitric oxide regulates angiogenesis through a functional switch involving thrombospondin-1
LA Ridnour, JS Isenberg, MG Espey, DD Thomas, DD Roberts, DA Wink
Proceedings of the National Academy of Sciences 102 (37), 13147-13152, 2005
Role of oxygen gradients in shaping redox relationships between the human intestine and its microbiota
MG Espey
Free Radical Biology and Medicine 55, 130-140, 2013
Nitroxyl anion exerts redox-sensitive positive cardiac inotropy in vivo by calcitonin gene-related peptide signaling
N Paolocci, WF Saavedra, KM Miranda, C Martignani, T Isoda, JM Hare, ...
Proceedings of the National Academy of Sciences 98 (18), 10463-10468, 2001
Hypoxic inducible factor 1α, extracellular signal-regulated kinase, and p53 are regulated by distinct threshold concentrations of nitric oxide
DD Thomas, MG Espey, LA Ridnour, LJ Hofseth, D Mancardi, CC Harris, ...
Proceedings of the National Academy of Sciences 101 (24), 8894-8899, 2004
A biochemical rationale for the discrete behavior of nitroxyl and nitric oxide in the cardiovascular system
KM Miranda, N Paolocci, T Katori, DD Thomas, E Ford, MD Bartberger, ...
Proceedings of the National Academy of Sciences 100 (16), 9196-9201, 2003
Thrombospondin-1 inhibits endothelial cell responses to nitric oxide in a cGMP-dependent manner
JS Isenberg, LA Ridnour, EM Perruccio, MG Espey, DA Wink, DD Roberts
Proceedings of the National Academy of Sciences 102 (37), 13141-13146, 2005
The biphasic nature of nitric oxide responses in tumor biology
LA Ridnour, DD Thomas, S Donzelli, MG Espey, DD Roberts, DA Wink, ...
Antioxidants & Redox Signaling 8 (7-8), 1329-1337, 2006
Activated human microglia produce the excitotoxin quinolinic acid
MG Espey, ON Chernyshev, JF Reinhard Jr, MAA Namboodiri, CA Colton
Neuroreport 8 (2), 431-434, 1997
Protein nitration is mediated by heme and free metals through Fenton-type chemistry: An alternative to the NO/O reaction
DD Thomas, MG Espey, MP Vitek, KM Miranda, DA Wink
Proceedings of the National Academy of Sciences 99 (20), 12691-12696, 2002
Pharmacologic ascorbate synergizes with gemcitabine in preclinical models of pancreatic cancer
MG Espey, P Chen, B Chalmers, J Drisko, AY Sun, M Levine, Q Chen
Free Radical Biology and Medicine 50 (11), 1610-1619, 2011
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