Biosynthetic characterization and chemoenzymatic assembly of the cryptophycins. Potent anticancer agents from Nostoc cyanobionts NA Magarvey, ZQ Beck, T Golakoti, Y Ding, U Huber, TK Hemscheidt, ... ACS chemical biology 1 (12), 766-779, 2006 | 201 | 2006 |
Identification of efficiently cleaved substrates for HIV-1 protease using a phage display library and use in inhibitor development ZQ Beck, L Hervio, PE Dawson, JH Elder, EL Madison Virology 274 (2), 391-401, 2000 | 111 | 2000 |
Increased isoprene production using the archaeal lower mevalonate pathway ZQ Beck, R Anthony, MC Miller, DV Vaviline, AT Nielsen US Patent 8,361,762, 2013 | 74 | 2013 |
Characterization of a feedback-resistant mevalonate kinase from the archaeon Methanosarcina mazei YA Primak, M Du, MC Miller, DH Wells, AT Nielsen, W Weyler, ZQ Beck Applied and environmental microbiology 77 (21), 7772-7778, 2011 | 72 | 2011 |
Chemoenzymatic synthesis of cryptophycin/arenastatin natural products ZQ Beck, CC Aldrich, NA Magarvey, GI Georg, DH Sherman Biochemistry 44 (41), 13457-13466, 2005 | 72 | 2005 |
Defining HIV-1 protease substrate selectivity ZQ Beck, GM Morris, JH Elder Current Drug Targets-Infectious Disorders 2 (1), 37-50, 2002 | 54 | 2002 |
Analysis of the cryptophycin P450 epoxidase reveals substrate tolerance and cooperativity Y Ding, WH Seufert, ZQ Beck, DH Sherman Journal of the American Chemical Society 130 (16), 5492-5498, 2008 | 53 | 2008 |
Alteration of substrate and inhibitor specificity of feline immunodeficiency virus protease YC Lin, Z Beck, T Lee, VD Le, GM Morris, AJ Olson, CH Wong, JH Elder Journal of virology 74 (10), 4710-4720, 2000 | 38 | 2000 |
Compositions and methods of PGL for the increased production of isoprene ZQ Beck, MA Cervin, AT Nielsen, CM Peres US Patent 8,455,236, 2013 | 37 | 2013 |
Molecular basis for the relative substrate specificity of human immunodeficiency virus type 1 and feline immunodeficiency virus proteases ZQ Beck, YC Lin, JH Elder Journal of virology 75 (19), 9458-9469, 2001 | 36 | 2001 |
Increased isoprene production using mevalonate kinase and isoprene synthase ZQ Beck, AR Calabria, MC Miller, DV Vaviline, DH Wells US Patent App. 12/560,305, 2010 | 30 | 2010 |
Enzymatic release and macrolactonization of cryptophycins from a safety-catch solid support W Seufert, ZQ Beck, DH Sherman Angewandte Chemie 119 (48), 9458, 2007 | 26 | 2007 |
Utilization of phosphoketolase in the production of mevalonate, isoprenoid precursors, and isoprene ZQ Beck, AC Eliot, CM Peres, DV Vaviline US Patent 8,993,305, 2015 | 25 | 2015 |
Structural basis for distinctions between substrate and inhibitor specificities for feline immunodeficiency virus and human immunodeficiency virus proteases YC Lin, Z Beck, GM Morris, AJ Olson, JH Elder Journal of virology 77 (12), 6589-6600, 2003 | 25 | 2003 |
Three-dimensional structure of isoprene synthase and its use thereof for generating variants ZQ Beck, RR Bott, CL Rife, DH Wells, JV Miller US Patent 8,518,686, 2013 | 23 | 2013 |
Recombinant anaerobic acetogenic bacteria for production of isoprene and/or industrial bio-products using synthesis gas ZQ Beck, MA Cervin, GK Chotani, BA Diner, J Fan, CM Peres, KJ Sanford, ... US Patent App. 14/091,449, 2014 | 22 | 2014 |
Characterization of the β-Methylaspartate-α-decarboxylase (CrpG) from the cryptophycin biosynthetic pathway ZQ Beck, DA Burr, DH Sherman Wiley-VCH Verlag, 2007 | 21 | 2007 |
Isoprene synthase variants for improved production of isoprene ZQ Beck, DA Estell, JV Miller, CL Rife, DH Wells US Patent 9,273,298, 2016 | 17 | 2016 |
Production of isoprene, isoprenoid, and isoprenoid precursors using an alternative lower mevalonate pathway ZQ Beck, J Mampel, G Meurer, MC Miller, KJ Sanford, DV Vaviline, ... | 16 | 2014 |
Recombinant microorganisms for enhanced production of mevalonate, isoprene, and isoprenoids ZQ Beck, MC Miller, CM Peres, YA Primak, JP Pucci, DH Wells US Patent 9,121,038, 2015 | 13 | 2015 |