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Emily Anne Day
Emily Anne Day
Verified email at tcd.ie
Title
Cited by
Cited by
Year
AMPK as a therapeutic target for treating metabolic diseases
EA Day, RJ Ford, GR Steinberg
Trends in Endocrinology & Metabolism 28 (8), 545-560, 2017
5032017
Liver-specific ATP-citrate lyase inhibition by bempedoic acid decreases LDL-C and attenuates atherosclerosis
SL Pinkosky, RS Newton, EA Day, RJ Ford, S Lhotak, RC Austin, ...
Nature Communications 7 (1), 13457, 2016
3652016
The Na+/glucose cotransporter inhibitor canagliflozin activates AMPK by inhibiting mitochondrial function and increasing cellular AMP levels
SA Hawley, RJ Ford, BK Smith, GJ Gowans, SJ Mancini, RD Pitt, EA Day, ...
Diabetes 65 (9), 2784-2794, 2016
3092016
Metformin-induced increases in GDF15 are important for suppressing appetite and promoting weight loss
EA Day, RJ Ford, BK Smith, P Mohammadi-Shemirani, MR Morrow, ...
Nature Metabolism 1 (12), 1202-1208, 2019
2002019
Metformin and salicylate synergistically activate liver AMPK, inhibit lipogenesis and improve insulin sensitivity
RJ Ford, MD Fullerton, SL Pinkosky, EA Day, JW Scott, JS Oakhill, ...
Biochemical Journal 468 (1), 125-132, 2015
1772015
GDF15: emerging biology and therapeutic applications for obesity and cardiometabolic disease
D Wang, EA Day, LK Townsend, D Djordjevic, SB Jørgensen, ...
Nature Reviews Endocrinology 17 (10), 592-607, 2021
1762021
Activation of liver AMPK with PF-06409577 corrects NAFLD and lowers cholesterol in rodent and primate preclinical models
RM Esquejo, CT Salatto, J Delmore, B Albuquerque, A Reyes, Y Shi, ...
EBioMedicine 31, 122-132, 2018
1142018
Long-chain fatty acyl-CoA esters regulate metabolism via allosteric control of AMPK β1 isoforms
SL Pinkosky, JW Scott, EM Desjardins, BK Smith, EA Day, RJ Ford, ...
Nature metabolism 2 (9), 873-881, 2020
882020
Salsalate (salicylate) uncouples mitochondria, improves glucose homeostasis, and reduces liver lipids independent of AMPK-β1
BK Smith, RJ Ford, EM Desjardins, AE Green, MC Hughes, VP Houde, ...
Diabetes 65 (11), 3352-3361, 2016
752016
Salicylate improves macrophage cholesterol homeostasis via activation of Ampk
MD Fullerton, RJ Ford, CP McGregor, ND LeBlond, SA Snider, SA Stypa, ...
Journal of lipid research 56 (5), 1025-1033, 2015
632015
The pesticide chlorpyrifos promotes obesity by inhibiting diet-induced thermogenesis in brown adipose tissue
B Wang, EE Tsakiridis, S Zhang, A Llanos, EM Desjardins, JM Yabut, ...
Nature communications 12 (1), 1-12, 2021
572021
Macrophage fumarate hydratase restrains mtRNA-mediated interferon production
A Hooftman, CG Peace, DG Ryan, EA Day, M Yang, AF McGettrick, M Yin, ...
Nature 615 (7952), 490-498, 2023
442023
Genetic deletion of mast cell serotonin synthesis prevents the development of obesity and insulin resistance
JM Yabut, EM Desjardins, EJ Chan, EA Day, JM Leroux, B Wang, ...
Nature communications 11 (1), 463, 2020
402020
The SGLT2 inhibitor canagliflozin suppresses lipid synthesis and interleukin-1 beta in ApoE deficient mice
EA Day, RJ Ford, JH Lu, R Lu, L Lundenberg, EM Desjardins, AE Green, ...
Biochemical Journal 477 (12), 2347-2361, 2020
292020
AMPK mediates energetic stress‐induced liver GDF15
LK Townsend, AJ Weber, EA Day, H Shamshoum, SJ Shaw, CGR Perry, ...
The FASEB Journal 35 (1), e21218, 2021
262021
GDF10 blocks hepatic PPARγ activation to protect against diet-induced liver injury
K Platko, PF Lebeau, JH Byun, SV Poon, EA Day, ME MacDonald, ...
Molecular metabolism 27, 62-74, 2019
172019
The phosphorylation of AMPKβ1 is critical for increasing autophagy and maintaining mitochondrial homeostasis in response to fatty acids
EM Desjardins, BK Smith, EA Day, S Ducommun, MJ Sanders, ...
Proceedings of the National Academy of Sciences 119 (48), e2119824119, 2022
82022
Salsalate reduces atherosclerosis through AMPKβ1 in mice
EA Day, RJ Ford, BK Smith, VP Houde, S Stypa, S Rehal, S Lhotak, ...
Molecular Metabolism 53, 101321, 2021
82021
Natural (dihydro) phenanthrene plant compounds are direct activators of AMPK through its allosteric drug and metabolite–binding site
MJ Sanders, Y Ratinaud, K Neopane, N Bonhoure, EA Day, O Ciclet, ...
Journal of Biological Chemistry 298 (5), 2022
72022
Dimethyl fumarate and 4-octyl itaconate are anticoagulants that suppress Tissue Factor in macrophages via inhibition of Type I Interferon
TAJ Ryan, A Hooftman, AM Rehill, MD Johansen, ECO Brien, ...
Nature Communications 14 (1), 3513, 2023
62023
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