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Ping-Chung Chen, Ph.D.
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Enhancement of proteasome activity by a small-molecule inhibitor of USP14
BH Lee, MJ Lee, S Park, DC Oh, S Elsasser, PC Chen, C Gartner, ...
Nature 467 (7312), 179-184, 2010
9832010
Deep multilayer brain proteomics identifies molecular networks in Alzheimer’s disease progression
B Bai, X Wang, Y Li, PC Chen, K Yu, KK Dey, JM Yarbro, X Han, BM Lutz, ...
Neuron 105 (6), 975-991. e7, 2020
3352020
U1 small nuclear ribonucleoprotein complex and RNA splicing alterations in Alzheimer’s disease
B Bai, CM Hales, PC Chen, Y Gozal, EB Dammer, JJ Fritz, X Wang, Q Xia, ...
Proceedings of the National Academy of Sciences 110 (41), 16562-16567, 2013
2952013
Inhibition of xanthine oxidase and suppression of intracellular reactive oxygen species in HL-60 cells by theaflavin-3, 3 ‘-digallate,(−)-epigallocatechin-3-gallate, and propyl …
JK Lin, PC Chen, CT Ho, SY Lin-Shiau
Journal of Agricultural and Food Chemistry 48 (7), 2736-2743, 2000
2492000
The proteasome-associated deubiquitinating enzyme Usp14 is essential for the maintenance of synaptic ubiquitin levels and the development of neuromuscular junctions
PC Chen, LN Qin, XM Li, BJ Walters, JA Wilson, L Mei, SM Wilson
Journal of Neuroscience 29 (35), 10909-10919, 2009
1292009
Integrated analysis of ultra-deep proteomes in cortex, cerebrospinal fluid and serum reveals a mitochondrial signature in Alzheimer’s disease
H Wang, KK Dey, PC Chen, Y Li, M Niu, JH Cho, X Wang, B Bai, Y Jiao, ...
Molecular neurodegeneration 15 (1), 1-20, 2020
1202020
Ubiquitin homeostasis is critical for synaptic development and function
PC Chen, BJ Bhattacharyya, J Hanna, H Minkel, JA Wilson, D Finley, ...
Journal of Neuroscience 31 (48), 17505-17513, 2011
1102011
Deep undepleted human serum proteome profiling toward biomarker discovery for Alzheimer’s disease
KK Dey, H Wang, M Niu, B Bai, X Wang, Y Li, JH Cho, H Tan, A Mishra, ...
Clinical proteomics 16 (1), 1-12, 2019
1082019
Proteomic landscape of Alzheimer’s Disease: novel insights into pathogenesis and biomarker discovery
B Bai, D Vanderwall, Y Li, X Wang, S Poudel, H Wang, KK Dey, PC Chen, ...
Molecular neurodegeneration 16 (1), 55, 2021
962021
Differential effects of Usp14 and Uch-L1 on the ubiquitin proteasome system and synaptic activity
BJ Walters, SL Campbell, PC Chen, AP Taylor, DG Schroeder, ...
Molecular and Cellular Neuroscience 39 (4), 539-548, 2008
872008
Neuronal ubiquitin homeostasis
J Hallengren, PC Chen, SM Wilson
Cell biochemistry and biophysics 67, 67-73, 2013
732013
Hypotriglyceridemic effect of Anka (a fermented rice product of Monascus sp.) in rats
IK Wang, SY Lin-Shiau, PC Chen, JK Lin
Journal of agricultural and food chemistry 48 (8), 3183-3189, 2000
522000
Ubiquitin-specific protease 14 regulates c-Jun N-terminal kinase signaling at the neuromuscular junction.
JH Vaden, BJ Bhattacharyya, PC Chen, JA Watson, AG Marshall, ...
Molecular Neurodegeneration 10 (3), doi:10.1186/1750-1326-10-3, 2015
492015
Sequential elution interactome analysis of the mind bomb 1 ubiquitin ligase reveals a novel role in dendritic spine outgrowth
J Mertz, H Tan, V Pagala, B Bai, PC Chen, Y Li, JH Cho, T Shaw, X Wang, ...
Molecular & Cellular Proteomics 14 (7), 1898-1910, 2015
462015
Transgenic rescue of ataxia mice reveals a male-specific sterility defect
S Crimmins, M Sutovsky, PC Chen, A Huffman, C Wheeler, DA Swing, ...
Developmental biology 325 (1), 33-42, 2009
432009
Selective modulation of the androgen receptor AF2 domain rescues degeneration in spinal bulbar muscular atrophy
NM Badders, A Korff, HC Miranda, PK Vuppala, RB Smith, BJ Winborn, ...
Nature medicine 24 (4), 427-437, 2018
392018
Usp14 deficiency increases tau phosphorylation without altering tau degradation or causing tau-dependent deficits
YN Jin, PC Chen, JA Watson, BJ Walters, SE Phillips, K Green, R Schmidt, ...
PloS one 7 (10), e47884, 2012
362012
Integrated approaches for analyzing U1-70K cleavage in Alzheimer’s disease
B Bai, PC Chen, CM Hales, Z Wu, V Pagala, AA High, AI Levey, JJ Lah, ...
Journal of proteome research 13 (11), 4526-4534, 2014
292014
Quantitative proteomics to decipher ubiquitin signaling
PC Chen, CH Na, J Peng
Amino acids 43, 1049-1060, 2012
292012
Distinct effects of ubiquitin overexpression on NMJ structure and motor performance in mice expressing catalytically inactive USP14
JH Vaden, JA Watson, AD Howard, PC Chen, JA Wilson, SM Wilson
Frontiers in Molecular Neuroscience 8, 11, 2015
232015
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Articles 1–20