Dr Martin J Lynch
Dr Martin J Lynch
UKHSA Genomics
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The regulation of biofilm development by quorum sensing in Aeromonas hydrophila
MJ Lynch, S Swift, DF Kirke, CW Keevil, CER Dodd, P Williams
Environmental microbiology 4 (1), 18-28, 2002
Quorum Sensing-Dependent Regulation and Blockade of Exoprotease Production in Aeromonas hydrophila
S Swift, MJ Lynch, L Fish, DF Kirke, JM Tomás, GSAB Stewart, P Williams
Infection and immunity 67 (10), 5192-5199, 1999
RNA silencing identifies PDE4D5 as the functionally relevant cAMP phosphodiesterase interacting with βarrestin to control the protein kinase A/AKAP79-mediated switching of the …
MJ Lynch, GS Baillie, A Mohamed, X Li, C Maisonneuve, E Klussmann, ...
Journal of Biological Chemistry 280 (39), 33178-33189, 2005
PGE1 stimulation of HEK293 cells generates multiple contiguous domains with different [cAMP]: role of compartmentalized phosphodiesterases
A Terrin, G Di Benedetto, V Pertegato, YF Cheung, G Baillie, MJ Lynch, ...
The Journal of cell biology 175 (3), 441-451, 2006
Scanning peptide array analyses identify overlapping binding sites for the signalling scaffold proteins, β-arrestin and RACK1, in cAMP-specific phosphodiesterase PDE4D5
GB Bolger, GS Baillie, X Li, MJ Lynch, P Herzyk, A Mohamed, ...
Biochemical Journal 398 (1), 23-36, 2006
p75 neurotrophin receptor regulates tissue fibrosis through inhibition of plasminogen activation via a PDE4/cAMP/PKA pathway
BD Sachs, GS Baillie, JR McCall, MA Passino, C Schachtrup, DA Wallace, ...
The Journal of cell biology 177 (6), 1119-1132, 2007
EPAC and PKA allow cAMP dual control over DNA-PK nuclear translocation
E Huston, MJ Lynch, A Mohamed, DM Collins, EV Hill, R MacLeod, ...
Proceedings of the National Academy of Sciences 105 (35), 12791-12796, 2008
In resting COS1 cells a dominant negative approach shows that specific, anchored PDE4 cAMP phosphodiesterase isoforms gate the activation, by basal cyclic AMP production, of …
A McCahill, T McSorley, E Huston, EV Hill, MJ Lynch, I Gall, G Keryer, ...
Cellular signalling 17 (9), 1158-1173, 2005
Cyclic AMP phosphodiesterase 4D (PDE4D) Tethers EPAC1 in a vascular endothelial cadherin (VE-Cad)-based signaling complex and controls cAMP-mediated vascular permeability
SN Rampersad, JD Ovens, E Huston, MB Umana, LS Wilson, ...
Journal of biological chemistry 285 (44), 33614-33622, 2010
Tyrosine 302 in RACK1 is essential for insulin-like growth factor-I-mediated competitive binding of PP2A and β1 integrin and for tumor cell proliferation and migration
PA Kiely, GS Baillie, MJ Lynch, MD Houslay, R O'Connor
Journal of Biological Chemistry 283 (34), 22952-22961, 2008
MEK1 binds directly to βarrestin1, influencing both its phosphorylation by ERK and the timing of its isoprenaline-stimulated internalization
D Meng, MJ Lynch, E Huston, M Beyermann, J Eichhorst, DR Adams, ...
Journal of Biological Chemistry 284 (17), 11425-11435, 2009
β-Arrestin 1 inhibits the GTPase-activating protein function of ARHGAP21, promoting activation of RhoA following angiotensin II type 1A receptor stimulation
DF Anthony, YY Sin, S Vadrevu, N Advant, JP Day, AM Byrne, MJ Lynch, ...
Molecular and cellular biology 31 (5), 1066-1075, 2011
The Aeromonas hydrophila LuxR homologue AhyR regulates the N-acyl homoserine lactone synthase, AhyI positively and negatively in a growth phase …
DF Kirke, S Swift, MJ Lynch, P Williams
FEMS microbiology letters 241 (1), 109-117, 2004
Dynamic regulation, desensitization, and cross-talk in discrete subcellular microdomains during β2-adrenoceptor and prostanoid receptor cAMP signaling
D Willoughby, GS Baillie, MJ Lynch, A Ciruela, MD Houslay, DMF Cooper
Journal of biological chemistry 282 (47), 34235-34249, 2007
Intracellular targeting of phosphodiesterase‐4 underpins compartmentalized cAMP signaling
MJ Lynch, EV Hill, MD Houslay
Current topics in developmental biology 75, 225-259, 2006
The role of the PDE4D cAMP phosphodiesterase in the regulation of glucagon‐like peptide‐1 release
WK Ong, FM Gribble, F Reimann, MJ Lynch, MD Houslay, GS Baillie, ...
British journal of pharmacology 157 (4), 633-644, 2009
cAMP-specific phosphodiesterase-4D5 (PDE4D5) provides a paradigm for understanding the unique non-redundant roles that PDE4 isoforms play in shaping compartmentalized cAMP cell …
MJ Lynch, GS Baillie, MD Houslay
Biochemical Society Transactions 35 (5), 938-941, 2007
Phosphodiesterase-4 influences the PKA phosphorylation status and membrane translocation of G-protein receptor kinase 2 (GRK2) in HEK-293β2 cells and cardiac myocytes
X Li, E Huston, MJ Lynch, MD Houslay, GS Baillie
Biochemical Journal 394 (2), 427-435, 2006
Expression, intracellular distribution and basis for lack of catalytic activity of the PDE4A7 isoform encoded by the human PDE4A cAMP-specific phosphodiesterase gene
LA Johnston, S Erdogan, YF Cheung, M Sullivan, R Barber, MJ Lynch, ...
Biochemical Journal 380 (2), 371-384, 2004
Reduced PDE4 expression and activity contributes to enhanced catecholamine-induced cAMP accumulation in adipocytes from FOXC2 transgenic mice
LM Gronning, GS Baillie, A Cederberg, MJ Lynch, MD Houslay, ...
FEBS letters 580 (17), 4126-4130, 2006
El sistema no puede realizar la operación en estos momentos. Inténtalo de nuevo más tarde.
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