John Zuris
John Zuris
Editas Medicine
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Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage
AC Komor, YB Kim, MS Packer, JA Zuris, DR Liu
Nature 533 (7603), 420-424, 2016
Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo
JA Zuris, DB Thompson, Y Shu, JP Guilinger, JL Bessen, JH Hu, ...
Nature biotechnology 33 (1), 73-80, 2015
Efficient delivery of genome-editing proteins using bioreducible lipid nanoparticles
M Wang, JA Zuris, F Meng, H Rees, S Sun, P Deng, Y Han, X Gao, ...
Proceedings of the National Academy of Sciences 113 (11), 2868-2873, 2016
Small molecule–triggered Cas9 protein with improved genome-editing specificity
KM Davis, V Pattanayak, DB Thompson, JA Zuris, DR Liu
Nature chemical biology 11 (5), 316-318, 2015
Facile transfer of [2Fe-2S] clusters from the diabetes drug target mitoNEET to an apo-acceptor protein
JA Zuris, Y Harir, AR Conlan, M Shvartsman, D Michaeli, S Tamir, ...
Proceedings of the National Academy of Sciences 108 (32), 13047-13052, 2011
Continuous directed evolution of DNA-binding proteins to improve TALEN specificity
BP Hubbard, AH Badran, JA Zuris, JP Guilinger, KM Davis, L Chen, ...
Nature methods 12 (10), 939-942, 2015
Crystal structure of Miner1: The redox-active 2Fe-2S protein causative in Wolfram Syndrome 2
AR Conlan, HL Axelrod, AE Cohen, EC Abresch, J Zuris, D Yee, ...
Journal of molecular biology 392 (1), 143-153, 2009
Use of cationic lipids to deliver CAS9
DR Liu, JA Zuris, DB Thompson
US Patent 9,737,604, 2017
Delivery system for functional nucleases
DR Liu, JA Zuris, DB Thompson
US Patent 9,526,784, 2016
Characterization of Arabidopsis NEET Reveals an Ancient Role for NEET Proteins in Iron Metabolism
R Nechushtai, AR Conlan, Y Harir, L Song, O Yogev, ...
The Plant Cell 24 (5), 2139-2154, 2012
Redox characterization of the FeS protein MitoNEET and impact of thiazolidinedione drug binding
DW Bak, JA Zuris, ML Paddock, PA Jennings, SJ Elliott
Biochemistry 48 (43), 10193-10195, 2009
AsCas12a ultra nuclease facilitates the rapid generation of therapeutic cell medicines
L Zhang, JA Zuris, R Viswanathan, JN Edelstein, R Turk, B Thommandru, ...
Nature communications 12 (1), 3908, 2021
Engineering the redox potential over a wide range within a new class of FeS proteins
JA Zuris, DA Halim, AR Conlan, EC Abresch, R Nechushtai, ML Paddock, ...
Journal of the American Chemical Society 132 (38), 13120-13122, 2010
Delivery system for functional nucleases
DR Liu, JA Zuris, DB Thompson
US Patent 10,682,410, 2020
Delivery of negatively charged proteins using cationic lipids
DR Liu, DB Thompson, JA Zuris
US Patent 9,999,671, 2018
Integrated strategy reveals the protein interface between cancer targets Bcl-2 and NAF-1
S Tamir, S Rotem-Bamberger, C Katz, F Morcos, KL Hailey, JA Zuris, ...
Proceedings of the National Academy of Sciences 111 (14), 5177-5182, 2014
Nutrient-deprivation autophagy factor-1 (NAF-1): biochemical properties of a novel cellular target for anti-diabetic drugs
S Tamir, JA Zuris, L Agranat, CH Lipper, AR Conlan, D Michaeli, Y Harir, ...
PLoS One 8 (5), e61202, 2013
NADPH inhibits [2Fe-2S] cluster protein transfer from diabetes drug target MitoNEET to an apo-acceptor protein
JA Zuris, SS Ali, H Yeh, TA Nguyen, R Nechushtai, ML Paddock, ...
Journal of Biological Chemistry 287 (15), 11649-11655, 2012
Detection and modulation of DNA translocations during multi-gene genome editing in T cells
A Bothmer, KW Gareau, HS Abdulkerim, F Buquicchio, L Cohen, ...
The CRISPR journal 3 (3), 177-187, 2020
Mutation of the His ligand in mitoNEET stabilizes the 2Fe–2S cluster despite conformational heterogeneity in the ligand environment
AR Conlan, ML Paddock, C Homer, HL Axelrod, AE Cohen, EC Abresch, ...
Acta Crystallographica Section D: Biological Crystallography 67 (6), 516-523, 2011
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