Joanne (Hulett) Hildebrand
Joanne (Hulett) Hildebrand
Senior Research Scientist, WEHI
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The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism
JM Murphy, PE Czabotar, JM Hildebrand, IS Lucet, JG Zhang, ...
Immunity 39 (3), 443-453, 2013
Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death
JM Hildebrand, MC Tanzer, IS Lucet, SN Young, SK Spall, P Sharma, ...
Proceedings of the National Academy of Sciences 111 (42), 15072-15077, 2014
MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis
AL Samson, Y Zhang, ND Geoghegan, XJ Gavin, KA Davies, ...
Nature communications 11 (1), 3151, 2020
EspL is a bacterial cysteine protease effector that cleaves RHIM proteins to block necroptosis and inflammation
JS Pearson, C Giogha, S Mühlen, U Nachbur, CLL Pham, Y Zhang, ...
Nature microbiology 2 (4), 1-10, 2017
Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis
EJ Petrie, JJ Sandow, AV Jacobsen, BJ Smith, MDW Griffin, IS Lucet, ...
Nature communications 9 (1), 2422, 2018
HSP90 activity is required for MLKL oligomerisation and membrane translocation and the induction of necroptotic cell death
AV Jacobsen, KN Lowes, MC Tanzer, IS Lucet, JM Hildebrand, EJ Petrie, ...
Cell death & disease 7 (1), e2051-e2051, 2016
Convergent evolution of receptors for protein import into mitochondria
AJ Perry, JM Hulett, VA Likić, T Lithgow, PR Gooley
Current Biology 16 (3), 221-229, 2006
A RIPK2 inhibitor delays NOD signalling events yet prevents inflammatory cytokine production
U Nachbur, CA Stafford, A Bankovacki, Y Zhan, LM Lindqvist, BK Fiil, ...
Nature communications 6 (1), 6442, 2015
A BAFF-R mutation associated with non-Hodgkin lymphoma alters TRAF recruitment and reveals new insights into BAFF-R signaling
JM Hildebrand, Z Luo, MK Manske, T Price-Troska, SC Ziesmer, W Lin, ...
Journal of Experimental Medicine 207 (12), 2569-2579, 2010
The transmembrane segment of Tom20 is recognized by Mim1 for docking to the mitochondrial TOM complex
JM Hulett, F Lueder, NC Chan, AJ Perry, P Wolynec, VA Likić, PR Gooley, ...
Journal of molecular biology 376 (3), 694-704, 2008
Roles of tumor necrosis factor receptor associated factor 3 (TRAF3) and TRAF5 in immune cell functions
JM Hildebrand, Z Yi, CM Buchta, J Poovassery, LL Stunz, GA Bishop
Immunological reviews 244 (1), 55-74, 2011
Insights into the evolution of divergent nucleotide-binding mechanisms among pseudokinases revealed by crystal structures of human and mouse MLKL
JM Murphy, IS Lucet, JM Hildebrand, MC Tanzer, SN Young, P Sharma, ...
Biochemical Journal 457 (3), 369-377, 2014
Evolutionary divergence of the necroptosis effector MLKL
MC Tanzer, I Matti, JM Hildebrand, SN Young, A Wardak, A Tripaydonis, ...
Cell Death & Differentiation 23 (7), 1185-1197, 2016
Necroptosis signalling is tuned by phosphorylation of MLKL residues outside the pseudokinase domain activation loop
MC Tanzer, A Tripaydonis, AI Webb, SN Young, LN Varghese, C Hall, ...
Biochemical Journal 471 (2), 255-265, 2015
Protein import into mitochondria: origins and functions today
R Lister, JM Hulett, T Lithgow, J Whelan
Molecular membrane biology 22 (1-2), 87-100, 2005
Necroptotic signaling is primed in Mycobacterium tuberculosis-infected macrophages, but its pathophysiological consequence in disease is restricted
MD Stutz, S Ojaimi, C Allison, S Preston, P Arandjelovic, JM Hildebrand, ...
Cell Death & Differentiation 25 (5), 951-965, 2018
Insane in the membrane: a structural perspective of MLKL function in necroptosis
EJ Petrie, JM Hildebrand, JM Murphy
Immunology and cell biology 95 (2), 152-159, 2017
A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction
JM Hildebrand, M Kauppi, IJ Majewski, Z Liu, AJ Cox, S Miyake, EJ Petrie, ...
Nature communications 11 (1), 3150, 2020
A FRET biosensor for necroptosis uncovers two different modes of the release of DAMPs
S Murai, Y Yamaguchi, Y Shirasaki, M Yamagishi, R Shindo, ...
Nature communications 9 (1), 4457, 2018
Environmental stresses inhibit and stimulate different protein import pathways in plant mitochondria
NL Taylor, C Rudhe, JM Hulett, T Lithgow, E Glaser, DA Day, AH Millar, ...
FEBS letters 547 (1-3), 125-130, 2003
El sistema no puede realizar la operación en estos momentos. Inténtalo de nuevo más tarde.
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