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Hubert Lam
Hubert Lam
Affini-T Therapeutics
Dirección de correo verificada de affinittx.com
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D-amino acids govern stationary phase cell wall remodeling in bacteria
H Lam, DC Oh, F Cava, CN Takacs, J Clardy, MA de Pedro, MK Waldor
Science 325 (5947), 1552-1555, 2009
6912009
Emerging knowledge of regulatory roles of d-amino acids in bacteria
F Cava, H Lam, MA De Pedro, MK Waldor
Cellular and Molecular Life Sciences 68, 817-831, 2011
4762011
Distinct pathways for modification of the bacterial cell wall by non‐canonical D‐amino acids
F Cava, MA De Pedro, H Lam, BM Davis, MK Waldor
The EMBO journal 30 (16), 3442-3453, 2011
3112011
The tubulin homologue FtsZ contributes to cell elongation by guiding cell wall precursor synthesis in Caulobacter crescentus
M Aaron, G Charbon, H Lam, H Schwarz, W Vollmer, C Jacobs‐Wagner
Molecular microbiology 64 (4), 938-952, 2007
2452007
A landmark protein essential for establishing and perpetuating the polarity of a bacterial cell
H Lam, WB Schofield, C Jacobs-Wagner
Cell 124 (5), 1011-1023, 2006
2092006
Cytokinesis monitoring during development: rapid pole-to-pole shuttling of a signaling protein by localized kinase and phosphatase in Caulobacter
JY Matroule, H Lam, DT Burnette, C Jacobs-Wagner
Cell 118 (5), 579-590, 2004
1722004
The asymmetric spatial distribution of bacterial signal transduction proteins coordinates cell cycle events
H Lam, JY Matroule, C Jacobs-Wagner
Developmental cell 5 (1), 149-159, 2003
1282003
Substrate specificity of an elongation‐specific peptidoglycan endopeptidase and its implications for cell wall architecture and growth of Vibrio cholerae
T Dörr, F Cava, H Lam, BM Davis, MK Waldor
Molecular Microbiology 89 (5), 949-962, 2013
582013
Differential Requirement for PBP1a and PBP1b in In Vivo and In Vitro Fitness of Vibrio cholerae
T Dörr, A Möll, MC Chao, F Cava, H Lam, BM Davis, MK Waldor
Infection and immunity 82 (5), 2115-2124, 2014
522014
An empirical antigen selection method identifies neoantigens that either elicit broad antitumor T-cell responses or drive tumor growth
H Lam, LK McNeil, H Starobinets, VL DeVault, RB Cohen, P Twardowski, ...
Cancer discovery 11 (3), 696-713, 2021
502021
A Novel Peptidoglycan Binding Protein Crucial for PBP1A-Mediated Cell Wall Biogenesis in Vibrio cholerae
T Dörr, H Lam, L Alvarez, F Cava, BM Davis, MK Waldor
PLoS genetics 10 (6), e1004433, 2014
462014
Antibodies to PhnD inhibit staphylococcal biofilms
H Lam, A Kesselly, S Stegalkina, H Kleanthous, JA Yethon
Infection and immunity 82 (9), 3764-3774, 2014
442014
Improving cancer immunotherapies through empirical neoantigen selection
C Nogueira, JK Kaufmann, H Lam, JB Flechtner
Trends in Cancer 4 (2), 97-100, 2018
222018
Limitations of murine models for assessment of antibody-mediated therapies or vaccine candidates against Staphylococcus epidermidis bloodstream infection
LE Cole, J Zhang, A Kesselly, NG Anosova, H Lam, H Kleanthous, ...
Infection and Immunity 84 (4), 1143-1149, 2016
92016
Asymmetric Reduction of (Z)-α, β-Dehydrotryptophanyl-containing Biological Peptides with Sulfur Functionality. Influence of Substrate on Stereoselectivity
A Hammadi, H Lam, M Gondry, A Ménez, R Genet
Tetrahedron 56 (26), 4473-4477, 2000
72000
Inhibigens, personal neoantigens that drive suppressive T cell responses, abrogate protection of therapeutic anti-tumor vaccines
VL DeVault, H Starobinets, S Adhikari, S Singh, S Rinaldi, B Classon, ...
The Journal of Immunology 204 (1_Supplement), 91.15-91.15, 2020
32020
Treatment methods
JB Flechtner, M Lossky-Elias, PM Carroll, H Lam, LK McNeil, WJ Broom
US Patent 10,859,566, 2020
22020
AFNT-211: A FAS-41BB–enhanced TCR-T cell therapy with stem-like properties targeting KRAS G12V-expressing solid tumors
MM Hoffmann, L Brown, M Campbell, K Pechhold, A Brate, X He, J Lee, ...
Cytokine 1, 50, 2023
12023
Preclinical development of safe and effective T cell receptors specific for mutant KRAS G12V and G12D peptides
T Martinov, R Perret, S Mureli, C McCurdy, A Vazquez, J Lee, J Webb, ...
MOLECULAR THERAPY 30 (4), 55-55, 2022
12022
The Association of Blood Glucose and Diabetes with Abdominal Aortic Aneurysm, Carotid Stenosis and Peripheral Arterial Disease: An Observational Study of 630,000 Patients …
D Morris, R Bulbulia, P Sherliker, R Clack, H Lam, J Carter, A Halliday, ...
European Journal of Vascular and Endovascular Surgery 58 (6), e155, 2019
12019
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