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Seong-Hoon Park
Seong-Hoon Park
Korea Institute of Toxicology
Dirección de correo verificada de kitox.re.kr - Página principal
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Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress
R Tao, MC Coleman, JD Pennington, O Ozden, SH Park, H Jiang, HS Kim, ...
Molecular cell 40 (6), 893-904, 2010
9712010
SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress
HS Kim, K Patel, K Muldoon-Jacobs, KS Bisht, N Aykin-Burns, ...
Cancer cell 17 (1), 41-52, 2010
8812010
SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity
HS Kim, A Vassilopoulos, RH Wang, T Lahusen, Z Xiao, X Xu, C Li, ...
Cancer cell 20 (4), 487-499, 2011
5802011
Acetylation of MnSOD directs enzymatic activity responding to cellular nutrient status or oxidative stress
O Ozden, SH Park, HS Kim, H Jiang, MC Coleman, DR Spitz, D Gius
Aging (Albany NY) 3 (2), 102, 2011
1862011
SIRT3 deacetylates and increases pyruvate dehydrogenase activity in cancer cells
O Ozden, SH Park, BA Wagner, HY Song, Y Zhu, A Vassilopoulos, B Jung, ...
Free Radical Biology and Medicine 76, 163-172, 2014
1782014
Sirt3, mitochondrial ROS, ageing, and carcinogenesis
SH Park, O Ozden, H Jiang, YI Cha, JD Pennington, N Aykin-Burns, ...
International journal of molecular sciences 12 (9), 6226-6239, 2011
1282011
Loss of NAD-dependent protein deacetylase sirtuin-2 alters mitochondrial protein acetylation and dysregulates mitophagy
G Liu, SH Park, M Imbesi, WJ Nathan, X Zou, Y Zhu, H Jiang, L Parisiadou, ...
Antioxidants & Redox Signaling 26 (15), 849-863, 2017
1202017
SIRT2 is a tumor suppressor that connects aging, acetylome, cell cycle signaling, and carcinogenesis
SH Park, Y Zhu, O Ozden, HS Kim, H Jiang, CX Deng, D Gius, ...
Translational cancer research 1 (1), 15, 2012
1102012
Sirtuin 2 regulates cellular iron homeostasis via deacetylation of transcription factor NRF2
X Yang, SH Park, HC Chang, JS Shapiro, A Vassilopoulos, KT Sawicki, ...
The Journal of clinical investigation 127 (4), 1505-1516, 2017
1072017
SIRT2-mediated deacetylation and tetramerization of pyruvate kinase directs glycolysis and tumor growth
SH Park, O Ozden, G Liu, HY Song, Y Zhu, Y Yan, X Zou, HJ Kang, ...
Cancer research 76 (13), 3802-3812, 2016
1032016
SIRT2 directs the replication stress response through CDK9 deacetylation
H Zhang, SH Park, BG Pantazides, O Karpiuk, MD Warren, CW Hardy, ...
Proceedings of the National Academy of Sciences 110 (33), 13546-13551, 2013
1012013
SIRT3-mediated dimerization of IDH2 directs cancer cell metabolism and tumor growth
X Zou, Y Zhu, SH Park, G Liu, J O'Brien, H Jiang, D Gius
Cancer research 77 (15), 3990-3999, 2017
752017
ATRIP deacetylation by SIRT2 drives ATR checkpoint activation by promoting binding to RPA-ssDNA
H Zhang, PSE Head, W Daddacha, SH Park, X Li, Y Pan, MZ Madden, ...
Cell reports 14 (6), 1435-1447, 2016
692016
SIRT1 regulates tyrosine hydroxylase expression and differentiation of neuroblastoma cells via FOXO3a
MJ Kim, K Ahn, SH Park, HJ Kang, BG Jang, SJ Oh, SM Oh, YJ Jeong, ...
FEBS letters 583 (7), 1183-1188, 2009
652009
Exploring the electrostatic repulsion model in the role of Sirt3 in directing MnSOD acetylation status and enzymatic activity
Y Zhu, SH Park, O Ozden, HS Kim, H Jiang, A Vassilopoulos, DR Spitz, ...
Free Radical Biology and Medicine 53 (4), 828-833, 2012
632012
Lysine 68 acetylation directs MnSOD as a tetrameric detoxification complex versus a monomeric tumor promoter
Nature Communications 10 (1), 2399, 2019
402019
Neuronal loss in primary long-term cortical culture involves neurodegeneration-like cell death via calpain and p35 processing, but not developmental apoptosis or aging
MJ Kim, SJ Oh, SH Park, HJ Kang, MH Won, TC Kang, JB Park, JI Kim, ...
Experimental & molecular medicine 39 (1), 14-26, 2007
402007
SIRT2 deletion enhances KRAS-induced tumorigenesis in vivo by regulating K147 acetylation status
HY Song, M Biancucci, HJ Kang, C O'Callaghan, SH Park, DR Principe, ...
Oncotarget 7 (49), 80336, 2016
362016
Effect of combined treatment with progesterone and tamoxifen on the growth and apoptosis of human ovarian cancer cells
JY Lee, JY Shin, HS Kim, JI Heo, YJ Kho, HJ Kang, SH Park, JY Lee
Oncology reports 27 (1), 87-93, 2012
332012
Expression of an oncogenic BARD1 splice variant impairs homologous recombination and predicts response to PARP-1 inhibitor therapy in colon cancer
O Ozden, F Bishehsari, J Bauer, SH Park, A Jana, SH Baik, JC Sporn, ...
Scientific reports 6 (1), 26273, 2016
312016
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