Hartmut Jaeschke
Hartmut Jaeschke
University Distinguished Professor and Chair, University of Kansas Medical Center
Dirección de correo verificada de kumc.edu
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Mechanisms of hepatotoxicity
H Jaeschke, GJ Gores, AI Cederbaum, JA Hinson, D Pessayre, ...
Toxicological sciences 65 (2), 166-176, 2002
Molecular mechanisms of hepatic ischemia-reperfusion injury and preconditioning
H Jaeschke
American Journal of Physiology-Gastrointestinal and Liver Physiology 284 (1 …, 2003
Neutrophil and Kupffer cell-induced oxidant stress and ischemia-reperfusion injury in rat liver
H Jaeschke, A Farhood
American Journal of Physiology-Gastrointestinal and Liver Physiology 260 (3 …, 1991
Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating …
P Godoy, NJ Hewitt, U Albrecht, ME Andersen, N Ansari, S Bhattacharya, ...
Archives of toxicology 87 (8), 1315-1530, 2013
Neutrophils contribute to ischemia/reperfusion injury in rat liver in vivo
H Jaeschke, A Farhood, CW Smith
The FASEB Journal 4 (15), 3355-3359, 1990
Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: lessons learned from acetaminophen hepatotoxicity
H Jaeschke, MR McGill, A Ramachandran
Drug metabolism reviews 44 (1), 88-106, 2012
Apoptosis versus oncotic necrosis in hepatic ischemia/reperfusion injury
H Jaeschke, JJ Lemasters
Gastroenterology 125 (4), 1246-1257, 2003
The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation
MR McGill, MR Sharpe, CD Williams, M Taha, SC Curry, H Jaeschke
The Journal of clinical investigation 122 (4), 1574-1583, 2012
Intracellular signaling mechanisms of acetaminophen-induced liver cell death
H Jaeschke, ML Bajt
Toxicological sciences 89 (1), 31-41, 2006
Mechanisms of neutrophil‐induced parenchymal cell injury
H Jaeschke, CW Smith
Journal of leukocyte biology 61 (6), 647-653, 1997
Mechanisms of Liver Injury. II. Mechanisms of neutrophil-induced liver cell injury during hepatic ischemia-reperfusion and other acute inflammatory conditions
H Jaeschke
American Journal of Physiology-Gastrointestinal and Liver Physiology 290 (6 …, 2006
Reactive oxygen and mechanisms of inflammatory liver injury: Present concepts
H Jaeschke
Journal of gastroenterology and hepatology 26, 173-179, 2011
The role of oxidant stress and reactive nitrogen species in acetaminophen hepatotoxicity
H Jaeschke, TR Knight, ML Bajt
Toxicology letters 144 (3), 279-288, 2003
Mitochondrial permeability transition in acetaminophen‐induced necrosis and apoptosis of cultured mouse hepatocytes
K Kon, JS Kim, H Jaeschke, JJ Lemasters
Hepatology 40 (5), 1170-1179, 2004
Mechanism of cell death during warm hepatic ischemia-reperfusion in rats: apoptosis or necrosis?
JS Gujral, TJ Bucci, A Farhood, H Jaeschke
Hepatology 33 (2), 397-405, 2001
Mode of cell death after acetaminophen overdose in mice: apoptosis or oncotic necrosis?
JS Gujral, TR Knight, A Farhood, ML Bajt, H Jaeschke
Toxicological sciences 67 (2), 322-328, 2002
Activation of caspase 3 (CPP32)-like proteases is essential for TNF-α-induced hepatic parenchymal cell apoptosis and neutrophil-mediated necrosis in a murine endotoxin shock model
H Jaeschke, MA Fisher, JA Lawson, CA Simmons, A Farhood, DA Jones
The Journal of Immunology 160 (7), 3480-3486, 1998
Reactive oxygen and mechanisms of inflammatory liver injury
H Jaeschke
Journal of gastroenterology and hepatology 15 (7), 718-724, 2000
Reactive oxygen and ischemia/reperfusion injury of the liver
H Jaeschke
Chemico-biological interactions 79 (2), 115-136, 1991
Metabolism and disposition of acetaminophen: recent advances in relation to hepatotoxicity and diagnosis
MR McGill, H Jaeschke
Pharmaceutical research 30 (9), 2174-2187, 2013
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