Disrupted alternative splicing for genes implicated in splicing and ciliogenesis causes PRPF31 retinitis pigmentosa A Buskin, L Zhu, V Chichagova, B Basu, S Mozaffari-Jovin, D Dolan, ... Nature communications 9 (1), 4234, 2018 | 191 | 2018 |
Human-induced pluripotent stem cells generate light responsive retinal organoids with variable and nutrient-dependent efficiency D Hallam, G Hilgen, B Dorgau, L Zhu, M Yu, S Bojic, P Hewitt, M Schmitt, ... Stem cells 36 (10), 1535-1551, 2018 | 175 | 2018 |
3D culture of human pluripotent stem cells in RGD-alginate hydrogel improves retinal tissue development NC Hunt, D Hallam, A Karimi, CB Mellough, J Chen, DHW Steel, M Lako Acta biomaterialia 49, 329-343, 2017 | 165 | 2017 |
Cellular regeneration strategies for macular degeneration: past, present and future V Chichagova, D Hallam, J Collin, D Zerti, B Dorgau, M Felemban, ... Eye 32 (5), 946-971, 2018 | 99 | 2018 |
An integrated transcriptional analysis of the developing human retina CB Mellough, R Bauer, J Collin, B Dorgau, D Zerti, DWP Dolan, CM Jones, ... Development 146 (2), dev169474, 2019 | 88 | 2019 |
An induced pluripotent stem cell patient specific model of complement factor H (Y402H) polymorphism displays characteristic features of age-related macular degeneration and … D Hallam, J Collin, S Bojic, V Chichagova, A Buskin, Y Xu, L Lafage, ... Stem Cells 35 (11), 2305-2320, 2017 | 71 | 2017 |
Decellularised extracellular matrix-derived peptides from neural retina and retinal pigment epithelium enhance the expression of synaptic markers and light responsiveness of … B Dorgau, M Felemban, G Hilgen, M Kiening, D Zerti, NC Hunt, M Doherty, ... Biomaterials 199, 63-75, 2019 | 69 | 2019 |
The application of biomaterials to tissue engineering neural retina and retinal pigment epithelium NC Hunt, D Hallam, V Chichagova, DH Steel, M Lako Advanced healthcare materials 7 (23), 1800226, 2018 | 49 | 2018 |
Extracellular matrix component expression in human pluripotent stem cell-derived retinal organoids recapitulates retinogenesis in vivo and reveals an important role for IMPG1 … M Felemban, B Dorgau, NC Hunt, D Hallam, D Zerti, R Bauer, Y Ding, ... Acta biomaterialia 74, 207-221, 2018 | 46 | 2018 |
Complement modulation reverses pathology in Y402H-retinal pigment epithelium cell model of age-related macular degeneration by restoring lysosomal function E Cerniauskas, M Kurzawa-Akanbi, L Xie, D Hallam, M Moya-Molina, ... Stem cells translational medicine 9 (12), 1585-1603, 2020 | 45 | 2020 |
Revisiting the role of factor H in age-related macular degeneration: insights from complement-mediated renal disease and rare genetic variants N Tzoumas, D Hallam, CL Harris, M Lako, D Kavanagh, DHW Steel Survey of Ophthalmology 66 (2), 378-401, 2021 | 29 | 2021 |
Laminin γ3 plays an important role in retinal lamination, photoreceptor organisation and ganglion cell differentiation B Dorgau, M Felemban, A Sharpe, R Bauer, D Hallam, DH Steel, ... Cell death & disease 9 (6), 615, 2018 | 29 | 2018 |
CD200 expression marks a population of quiescent limbal epithelial stem cells with holoclone forming ability S Bojic, D Hallam, N Alcada, A Ghareeb, R Queen, S Pervinder, H Buck, ... Stem Cells 36 (11), 1723-1735, 2018 | 28 | 2018 |
Human iPSC disease modelling reveals functional and structural defects in retinal pigment epithelial cells harbouring the m. 3243A> G mitochondrial DNA mutation V Chichagova, D Hallam, J Collin, A Buskin, G Saretzki, L Armstrong, ... Scientific reports 7 (1), 12320, 2017 | 27 | 2017 |
Dietary restriction mitigates age-related accumulation of DNA damage, but not all changes in mouse corneal epithelium D Hallam, T Wan, G Saretzki Experimental Gerontology 67, 72-79, 2015 | 6 | 2015 |
Human iPSC-derived RPE and retinal organoids reveal impaired alternative splicing of genes involved in pre-mRNA splicing in PRPF31 autosomal dominant retinitis pigmentosa A Buskin, L Zhu, V Chichagova, B Basu, S Mozaffari-Jovin, D Dolan, ... BioRxiv, 232397, 2017 | 3 | 2017 |
Using statistical models to identify key variables critical for generation of retinal organoids from iPSC V Chichagova, D Hallam, M Nicholds, R Thomas, M Lako, L Armstrong Investigative Ophthalmology & Visual Science 59 (9), 565-565, 2018 | 1 | 2018 |
In Reply to the Letter to the Editor from Anderson et al.: An Induced Pluripotent Stem Cell Patient Specific Model of Complement Factor H (Y402H) Polymorphism Displays … D Hallam, D Rawlings, D Steel, L Armstrong, M Lako Stem Cells 36 (4), 627-629, 2018 | 1 | 2018 |
The effect of hypoxia on the growth of limbal stem cells D Hallam, C Henein, S Miwa, S Ahmad, G Saretzki Investigative Ophthalmology & Visual Science 54 (15), 982-982, 2013 | 1 | 2013 |
Limbal stem cells, telomerase activity and telomere length decline with increasing culture of human limbal epithelium S Ahmad, A Bianchi, D Hallam, G Saretzki Investigative Ophthalmology & Visual Science 52 (14), 5134-5134, 2011 | 1 | 2011 |