D Hallam
D Hallam
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Disrupted alternative splicing for genes implicated in splicing and ciliogenesis causes PRPF31 retinitis pigmentosa
A Buskin, L Zhu, V Chichagova, B Basu, S Mozaffari-Jovin, D Dolan, ...
Nature communications 9 (1), 4234, 2018
Human-induced pluripotent stem cells generate light responsive retinal organoids with variable and nutrient-dependent efficiency
D Hallam, G Hilgen, B Dorgau, L Zhu, M Yu, S Bojic, P Hewitt, M Schmitt, ...
Stem Cells 36 (10), 1535-1551, 2018
3D culture of human pluripotent stem cells in RGD-alginate hydrogel improves retinal tissue development
NC Hunt, D Hallam, A Karimi, CB Mellough, J Chen, DHW Steel, M Lako
Acta biomaterialia 49, 329-343, 2017
Cellular regeneration strategies for macular degeneration: past, present and future
V Chichagova, D Hallam, J Collin, D Zerti, B Dorgau, M Felemban, ...
Eye 32 (5), 946-971, 2018
An integrated transcriptional analysis of the developing human retina
CB Mellough, R Bauer, J Collin, B Dorgau, D Zerti, DWP Dolan, CM Jones, ...
Development 146 (2), dev169474, 2019
An induced pluripotent stem cell patient specific model of complement factor H (Y402H) polymorphism displays characteristic features of age-related macular degeneration and …
D Hallam, J Collin, S Bojic, V Chichagova, A Buskin, Y Xu, L Lafage, ...
Stem Cells 35 (11), 2305-2320, 2017
Decellularised extracellular matrix-derived peptides from neural retina and retinal pigment epithelium enhance the expression of synaptic markers and light responsiveness of …
B Dorgau, M Felemban, G Hilgen, M Kiening, D Zerti, NC Hunt, M Doherty, ...
Biomaterials 199, 63-75, 2019
The application of biomaterials to tissue engineering neural retina and retinal pigment epithelium
NC Hunt, D Hallam, V Chichagova, DH Steel, M Lako
Advanced healthcare materials 7 (23), 1800226, 2018
Complement modulation reverses pathology in Y402H-retinal pigment epithelium cell model of age-related macular degeneration by restoring lysosomal function
E Cerniauskas, M Kurzawa-Akanbi, L Xie, D Hallam, M Moya-Molina, ...
Stem cells translational medicine 9 (12), 1585-1603, 2020
Extracellular matrix component expression in human pluripotent stem cell-derived retinal organoids recapitulates retinogenesis in vivo and reveals an important role for IMPG1 …
M Felemban, B Dorgau, NC Hunt, D Hallam, D Zerti, R Bauer, Y Ding, ...
Acta biomaterialia 74, 207-221, 2018
CD200 expression marks a population of quiescent limbal epithelial stem cells with holoclone forming ability
S Bojic, D Hallam, N Alcada, A Ghareeb, R Queen, S Pervinder, H Buck, ...
Stem Cells 36 (11), 1723-1735, 2018
Revisiting the role of factor H in age-related macular degeneration: insights from complement-mediated renal disease and rare genetic variants
N Tzoumas, D Hallam, CL Harris, M Lako, D Kavanagh, DHW Steel
Survey of Ophthalmology 66 (2), 378-401, 2021
Laminin γ3 plays an important role in retinal lamination, photoreceptor organisation and ganglion cell differentiation
B Dorgau, M Felemban, A Sharpe, R Bauer, D Hallam, DH Steel, ...
Cell Death & Disease 9 (6), 615, 2018
Human iPSC disease modelling reveals functional and structural defects in retinal pigment epithelial cells harbouring the m. 3243A> G mitochondrial DNA mutation
V Chichagova, D Hallam, J Collin, A Buskin, G Saretzki, L Armstrong, ...
Scientific reports 7 (1), 12320, 2017
Dietary restriction mitigates age-related accumulation of DNA damage, but not all changes in mouse corneal epithelium
D Hallam, T Wan, G Saretzki
Experimental Gerontology 67, 72-79, 2015
Human iPSC-derived RPE and retinal organoids reveal impaired alternative splicing of genes involved in pre-mRNA splicing in PRPF31 autosomal dominant retinitis pigmentosa
A Buskin, L Zhu, V Chichagova, B Basu, S Mozaffari-Jovin, D Dolan, ...
BioRxiv, 232397, 2017
Splicing factor PRPF31 retinitis pigmentosa (RP11) is caused by disrupted alternative splicing programmes for genes implicated in pre-mRNA splicing, cellular adhesion and …
A Buskin, L Zhu, V Chichagova, B Basu, S Mozaffari-Jovin, D Dolan, ...
Nature communications., 2019
Using statistical models to identify key variables critical for generation of retinal organoids from iPSC
V Chichagova, D Hallam, M Nicholds, R Thomas, M Lako, L Armstrong
Investigative Ophthalmology & Visual Science 59 (9), 565-565, 2018
In Reply to the Letter to the Editor from Anderson et al.: An Induced Pluripotent Stem Cell Patient Specific Model of Complement Factor H (Y402H) Polymorphism Displays …
D Hallam, D Rawlings, D Steel, L Armstrong, M Lako
Stem Cells 36 (4), 627-629, 2018
The effect of hypoxia on the growth of limbal stem cells
D Hallam, C Henein, S Miwa, S Ahmad, G Saretzki
Investigative Ophthalmology & Visual Science 54 (15), 982-982, 2013
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