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James M. Murphy
James M. Murphy
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The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism
JM Murphy, PE Czabotar, JM Hildebrand, IS Lucet, JG Zhang, ...
Immunity 39 (3), 443-453, 2013
11482013
RIPK1 regulates RIPK3-MLKL-driven systemic inflammation and emergency hematopoiesis
JA Rickard, JA O’Donnell, JM Evans, N Lalaoui, AR Poh, TW Rogers, ...
Cell 157 (5), 1175-1188, 2014
5952014
Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death
JM Hildebrand, MC Tanzer, IS Lucet, SN Young, SK Spall, P Sharma, ...
Proceedings of the National Academy of Sciences 111 (42), 15072-15077, 2014
5602014
Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner
SA Conos, KW Chen, D De Nardo, H Hara, L Whitehead, G Núñez, ...
Proceedings of the National Academy of Sciences 114 (6), E961-E969, 2017
3932017
The molecular regulation of Janus kinase (JAK) activation
JJ Babon, IS Lucet, JM Murphy, NA Nicola, LN Varghese
Biochemical Journal 462 (1), 1-13, 2014
3702014
The molecular basis of JAK/STAT inhibition by SOCS1
NPD Liau, A Laktyushin, IS Lucet, JM Murphy, S Yao, E Whitlock, ...
Nature communications 9 (1), 1558, 2018
3682018
Suppression of cytokine signaling by SOCS3: characterization of the mode of inhibition and the basis of its specificity
JJ Babon, NJ Kershaw, JM Murphy, LN Varghese, A Laktyushin, ...
Immunity 36 (2), 239-250, 2012
3162012
SOCS3 binds specific receptor–JAK complexes to control cytokine signaling by direct kinase inhibition
NJ Kershaw, JM Murphy, NPD Liau, LN Varghese, A Laktyushin, ...
Nature structural & molecular biology 20 (4), 469-476, 2013
3052013
Necroptosis and ferroptosis are alternative cell death pathways that operate in acute kidney failure
T Müller, C Dewitz, J Schmitz, AS Schröder, JH Bräsen, BR Stockwell, ...
Cellular and Molecular Life Sciences 74, 3631-3645, 2017
2952017
MK2 phosphorylates RIPK1 to prevent TNF-induced cell death
I Jaco, A Annibaldi, N Lalaoui, R Wilson, T Tenev, L Laurien, C Kim, ...
Molecular cell 66 (5), 698-710. e5, 2017
2742017
A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties
JM Murphy, Q Zhang, SN Young, ML Reese, FP Bailey, PA Eyers, ...
Biochemical Journal 457 (2), 323-334, 2014
2732014
TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice
JA Rickard, H Anderton, N Etemadi, U Nachbur, M Darding, N Peltzer, ...
Elife 3, e03464, 2014
2562014
Regulated necrosis in kidney ischemia-reperfusion injury
A Pefanis, FL Ierino, JM Murphy, PJ Cowan
Kidney international 96 (2), 291-301, 2019
2362019
MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis
AL Samson, Y Zhang, ND Geoghegan, XJ Gavin, KA Davies, ...
Nature communications 11 (1), 3151, 2020
2232020
Transferrin receptor 1 is a reticulocyte-specific receptor for Plasmodium vivax
J Gruszczyk, U Kanjee, LJ Chan, S Menant, B Malleret, NTY Lim, ...
Science 359 (6371), 48-55, 2018
1972018
EspL is a bacterial cysteine protease effector that cleaves RHIM proteins to block necroptosis and inflammation
JS Pearson, C Giogha, S Mühlen, U Nachbur, CLL Pham, Y Zhang, ...
Nature microbiology 2 (4), 1-10, 2017
1782017
Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis
EJ Petrie, JJ Sandow, AV Jacobsen, BJ Smith, MDW Griffin, IS Lucet, ...
Nature communications 9 (1), 2422, 2018
1762018
TNF can activate RIPK3 and cause programmed necrosis in the absence of RIPK1
DM Moujalled, WD Cook, T Okamoto, J Murphy, KE Lawlor, JE Vince, ...
Cell death & disease 4 (1), e465-e465, 2013
1752013
cIAPs and XIAP regulate myelopoiesis through cytokine production in an RIPK1-and RIPK3-dependent manner
WWL Wong, JE Vince, N Lalaoui, KE Lawlor, D Chau, A Bankovacki, ...
Blood, The Journal of the American Society of Hematology 123 (16), 2562-2572, 2014
1722014
HSP90 activity is required for MLKL oligomerisation and membrane translocation and the induction of necroptotic cell death
AV Jacobsen, KN Lowes, MC Tanzer, IS Lucet, JM Hildebrand, EJ Petrie, ...
Cell death & disease 7 (1), e2051-e2051, 2016
1542016
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