Lukáš Górecki
Lukáš Górecki
Fakultní nemocnice Hradec Králové
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SAR study to find optimal cholinesterase reactivator against organophosphorous nerve agents and pesticides
L Gorecki, J Korabecny, K Musilek, D Malinak, E Nepovimova, R Dolezal, ...
Archives of toxicology 90, 2831-2859, 2016
Discovery of ATR kinase inhibitor berzosertib (VX-970, M6620): Clinical candidate for cancer therapy
L Gorecki, M Andrs, M Rezacova, J Korabecny
Pharmacology & therapeutics 210, 107518, 2020
Clinical candidates targeting the ATR–CHK1–WEE1 axis in cancer
L Gorecki, M Andrs, J Korabecny
Cancers 13 (4), 795, 2021
Profiling donepezil template into multipotent hybrids with antioxidant properties
E Mezeiova, K Spilovska, E Nepovimova, L Gorecki, O Soukup, R Dolezal, ...
Journal of enzyme inhibition and medicinal chemistry 33 (1), 583-606, 2018
7-Methoxytacrine-p-Anisidine Hybrids as Novel Dual Binding Site Acetylcholinesterase Inhibitors for Alzheimer’s Disease Treatment
J Korabecny, M Andrs, E Nepovimova, R Dolezal, K Babkova, A Horova, ...
Molecules 20 (12), 22084-22101, 2015
Progress in acetylcholinesterase reactivators and in the treatment of organophosphorus intoxication: a patent review (2006–2016)
L Gorecki, J Korabecny, K Musilek, E Nepovimova, D Malinak, T Kucera, ...
Expert opinion on therapeutic patents 27 (9), 971-985, 2017
Rational design, synthesis, and evaluation of uncharged,“smart” bis-oxime antidotes of organophosphate-inhibited human acetylcholinesterase
L Gorecki, O Gerlits, X Kong, X Cheng, DK Blumenthal, P Taylor, ...
Journal of Biological Chemistry 295 (13), 4079-4092, 2020
A 7-methoxytacrine–4-pyridinealdoxime hybrid as a novel prophylactic agent with reactivation properties in organophosphate intoxication
E Nepovimova, J Korabecny, R Dolezal, TD Nguyen, D Jun, O Soukup, ...
Toxicology research 5 (4), 1012-1016, 2016
In vitro and in silico evaluation of non-quaternary reactivators of AChE as antidotes of organophosphorus poisoning-a new hope or a blind alley?
O Soukup, J Korabecny, D Malinak, E Nepovimova, NL Pham, K Musilek, ...
Medicinal Chemistry 14 (3), 281-292, 2018
Donepezil derivatives targeting amyloid-β cascade in Alzheimer's disease
E Mezeiova, K Chalupova, E Nepovimova, L Gorecki, L Prchal, D Malinak, ...
Current Alzheimer Research 16 (9), 772-800, 2019
Oxime K203: a drug candidate for the treatment of tabun intoxication
L Gorecki, O Soukup, T Kucera, D Malinak, D Jun, K Kuca, K Musilek, ...
Archives of Toxicology 93, 673-691, 2019
Synthesis, in vitro screening and molecular docking of isoquinolinium-5-carbaldoximes as acetylcholinesterase and butyrylcholinesterase reactivators
D Malinak, R Dolezal, V Hepnarova, M Hozova, R Andrys, P Bzonek, ...
Journal of Enzyme Inhibition and Medicinal Chemistry 35 (1), 478-488, 2020
Physicochemistry shapes bioactivity landscape of pan-ABC transporter modulators: anchor point for innovative Alzheimer's disease therapeutics
V Namasivayam, K Stefan, L Gorecki, J Korabecny, O Soukup, ...
International Journal of Biological Macromolecules 217, 775-791, 2022
Countermeasures in organophosphorus intoxication: pitfalls and prospects
L Gorecki, O Soukup, J Korabecny
Trends in Pharmacological Sciences 43 (7), 593-606, 2022
Phenothiazine-Tacrine Heterodimers: Pursuing Multitarget Directed Approach in Alzheimer’s Disease
L Gorecki, E Uliassi, M Bartolini, J Janockova, M Hrabinova, V Hepnarova, ...
ACS Chemical Neuroscience 12 (9), 1698-1715, 2021
Structure-activity relationships of dually-acting acetylcholinesterase inhibitors derived from tacrine on N-methyl-d-Aspartate receptors
L Gorecki, A Misiachna, J Damborsky, R Dolezal, J Korabecny, L Cejkova, ...
European Journal of Medicinal Chemistry 219, 113434, 2021
Cysteine-Targeted Insecticides against A. gambiae Acetylcholinesterase Are Neither Selective nor Reversible Inhibitors
L Gorecki, R Andrys, M Schmidt, T Kucera, M Psotka, B Svobodova, ...
ACS Medicinal Chemistry Letters 11 (1), 65-71, 2019
Development of versatile and potent monoquaternary reactivators of acetylcholinesterase
L Gorecki, V Hepnarova, JZ Karasova, M Hrabinova, C Courageux, J Dias, ...
Archives of Toxicology 95, 985-1001, 2021
Huprine Y–Tryptophan heterodimers with potential implication to Alzheimer’s disease treatment
E Mezeiova, M Hrabinova, V Hepnarova, D Jun, J Janockova, L Muckova, ...
Bioorganic & Medicinal Chemistry Letters 43, 128100, 2021
Tacroximes: novel unique compounds for the recovery of organophosphorus-inhibited acetylcholinesterase
L Gorecki, L Junova, T Kucera, V Hepnarova, L Prchal, T Kobrlova, ...
Future Medicinal Chemistry 11 (20), 2625-2634, 2019
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