SAR study to find optimal cholinesterase reactivator against organophosphorous nerve agents and pesticides L Gorecki, J Korabecny, K Musilek, D Malinak, E Nepovimova, R Dolezal, ... Archives of toxicology 90, 2831-2859, 2016 | 117 | 2016 |
Discovery of ATR kinase inhibitor berzosertib (VX-970, M6620): Clinical candidate for cancer therapy L Gorecki, M Andrs, M Rezacova, J Korabecny Pharmacology & therapeutics 210, 107518, 2020 | 95 | 2020 |
Clinical candidates targeting the ATR–CHK1–WEE1 axis in cancer L Gorecki, M Andrs, J Korabecny Cancers 13 (4), 795, 2021 | 73 | 2021 |
Profiling donepezil template into multipotent hybrids with antioxidant properties E Mezeiova, K Spilovska, E Nepovimova, L Gorecki, O Soukup, R Dolezal, ... Journal of enzyme inhibition and medicinal chemistry 33 (1), 583-606, 2018 | 61 | 2018 |
7-Methoxytacrine-p-Anisidine Hybrids as Novel Dual Binding Site Acetylcholinesterase Inhibitors for Alzheimer’s Disease Treatment J Korabecny, M Andrs, E Nepovimova, R Dolezal, K Babkova, A Horova, ... Molecules 20 (12), 22084-22101, 2015 | 50 | 2015 |
Progress in acetylcholinesterase reactivators and in the treatment of organophosphorus intoxication: a patent review (2006–2016) L Gorecki, J Korabecny, K Musilek, E Nepovimova, D Malinak, T Kucera, ... Expert opinion on therapeutic patents 27 (9), 971-985, 2017 | 48 | 2017 |
Rational design, synthesis, and evaluation of uncharged,“smart” bis-oxime antidotes of organophosphate-inhibited human acetylcholinesterase L Gorecki, O Gerlits, X Kong, X Cheng, DK Blumenthal, P Taylor, ... Journal of Biological Chemistry 295 (13), 4079-4092, 2020 | 33* | 2020 |
In vitro and in silico evaluation of non-quaternary reactivators of AChE as antidotes of organophosphorus poisoning-a new hope or a blind alley? O Soukup, J Korabecny, D Malinak, E Nepovimova, NL Pham, K Musilek, ... Medicinal Chemistry 14 (3), 281-292, 2018 | 29 | 2018 |
Countermeasures in organophosphorus intoxication: pitfalls and prospects L Gorecki, O Soukup, J Korabecny Trends in Pharmacological Sciences 43 (7), 593-606, 2022 | 28 | 2022 |
A 7-methoxytacrine–4-pyridinealdoxime hybrid as a novel prophylactic agent with reactivation properties in organophosphate intoxication E Nepovimova, J Korabecny, R Dolezal, TD Nguyen, D Jun, O Soukup, ... Toxicology research 5 (4), 1012-1016, 2016 | 27 | 2016 |
Donepezil derivatives targeting amyloid-β cascade in Alzheimer's disease E Mezeiova, K Chalupova, E Nepovimova, L Gorecki, L Prchal, D Malinak, ... Current Alzheimer Research 16 (9), 772-800, 2019 | 26 | 2019 |
Physicochemistry shapes bioactivity landscape of pan-ABC transporter modulators: anchor point for innovative Alzheimer's disease therapeutics V Namasivayam, K Stefan, L Gorecki, J Korabecny, O Soukup, ... International Journal of Biological Macromolecules 217, 775-791, 2022 | 23 | 2022 |
Synthesis, in vitro screening and molecular docking of isoquinolinium-5-carbaldoximes as acetylcholinesterase and butyrylcholinesterase reactivators D Malinak, R Dolezal, V Hepnarova, M Hozova, R Andrys, P Bzonek, ... Journal of Enzyme Inhibition and Medicinal Chemistry 35 (1), 478-488, 2020 | 22 | 2020 |
Oxime K203: a drug candidate for the treatment of tabun intoxication L Gorecki, O Soukup, T Kucera, D Malinak, D Jun, K Kuca, K Musilek, ... Archives of Toxicology 93, 673-691, 2019 | 21 | 2019 |
Phenothiazine-Tacrine Heterodimers: Pursuing Multitarget Directed Approach in Alzheimer’s Disease L Gorecki, E Uliassi, M Bartolini, J Janockova, M Hrabinova, V Hepnarova, ... ACS Chemical Neuroscience 12 (9), 1698-1715, 2021 | 20 | 2021 |
Structure-activity relationships of dually-acting acetylcholinesterase inhibitors derived from tacrine on N-methyl-d-Aspartate receptors L Gorecki, A Misiachna, J Damborsky, R Dolezal, J Korabecny, L Cejkova, ... European Journal of Medicinal Chemistry 219, 113434, 2021 | 18 | 2021 |
Development of versatile and potent monoquaternary reactivators of acetylcholinesterase L Gorecki, V Hepnarova, JZ Karasova, M Hrabinova, C Courageux, J Dias, ... Archives of Toxicology 95, 985-1001, 2021 | 13 | 2021 |
Cysteine-Targeted Insecticides against A. gambiae Acetylcholinesterase Are Neither Selective nor Reversible Inhibitors L Gorecki, R Andrys, M Schmidt, T Kucera, M Psotka, B Svobodova, ... ACS Medicinal Chemistry Letters 11 (1), 65-71, 2019 | 13 | 2019 |
A review of the synthesis of quaternary acetylcholinesterase reactivators D Malinak, J Korabecny, O Soukup, L Gorecki, E Nepovimova, M Psotka, ... Current Organic Chemistry 22 (16), 1619-1648, 2018 | 12 | 2018 |
Huprine Y–Tryptophan heterodimers with potential implication to Alzheimer’s disease treatment E Mezeiova, M Hrabinova, V Hepnarova, D Jun, J Janockova, L Muckova, ... Bioorganic & Medicinal Chemistry Letters 43, 128100, 2021 | 9 | 2021 |