Maria C Tanzer
Maria C Tanzer
Max-Planck of Biochemistry
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Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV
A Stukalov, V Girault, V Grass, O Karayel, V Bergant, C Urban, DA Haas, ...
Nature 594 (7862), 246-252, 2021
Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death
JM Hildebrand, MC Tanzer, IS Lucet, SN Young, SK Spall, P Sharma, ...
Proceedings of the National Academy of Sciences 111 (42), 15072-15077, 2014
NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase‐4 and caspase‐5
PJ Baker, D Boucher, D Bierschenk, C Tebartz, PG Whitney, DB D'Silva, ...
European journal of immunology 45 (10), 2918-2926, 2015
The pseudokinase MLKL and the kinase RIPK3 have distinct roles in autoimmune disease caused by loss of death-receptor-induced apoptosis
S Alvarez-Diaz, CP Dillon, N Lalaoui, MC Tanzer, DA Rodriguez, A Lin, ...
Immunity 45 (3), 513-526, 2016
Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis
EJ Petrie, JJ Sandow, AV Jacobsen, BJ Smith, MDW Griffin, IS Lucet, ...
Nature communications 9 (1), 2422, 2018
The caspase-8 inhibitor emricasan combines with the SMAC mimetic birinapant to induce necroptosis and treat acute myeloid leukemia
G Brumatti, C Ma, N Lalaoui, NY Nguyen, M Navarro, MC Tanzer, ...
Science translational medicine 8 (339), 339ra69-339ra69, 2016
HSP90 activity is required for MLKL oligomerisation and membrane translocation and the induction of necroptotic cell death
AV Jacobsen, KN Lowes, MC Tanzer, IS Lucet, JM Hildebrand, EJ Petrie, ...
Cell death & disease 7 (1), e2051-e2051, 2016
Targeting of Fn14 prevents cancer-induced cachexia and prolongs survival
AJ Johnston, KT Murphy, L Jenkinson, D Laine, K Emmrich, P Faou, ...
Cell 162 (6), 1365-1378, 2015
The polycomb repressive complex 2 governs life and death of peripheral T cells
Y Zhang, S Kinkel, J Maksimovic, E Bandala-Sanchez, MC Tanzer, ...
Blood, The Journal of the American Society of Hematology 124 (5), 737-749, 2014
Insights into the evolution of divergent nucleotide-binding mechanisms among pseudokinases revealed by crystal structures of human and mouse MLKL
JM Murphy, IS Lucet, JM Hildebrand, MC Tanzer, SN Young, P Sharma, ...
Biochemical Journal 457 (3), 369-377, 2014
Evolutionary divergence of the necroptosis effector MLKL
MC Tanzer, I Matti, JM Hildebrand, SN Young, A Wardak, A Tripaydonis, ...
Cell Death & Differentiation 23 (7), 1185-1197, 2016
Necroptosis signalling is tuned by phosphorylation of MLKL residues outside the pseudokinase domain activation loop
MC Tanzer, A Tripaydonis, AI Webb, SN Young, LN Varghese, C Hall, ...
Biochemical Journal 471 (2), 255-265, 2015
TRAF2 regulates TNF and NF-κB signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1
N Etemadi, M Chopin, H Anderton, MC Tanzer, JA Rickard, W Abeysekera, ...
elife 4, e10592, 2015
Data-independent acquisition method for ubiquitinome analysis reveals regulation of circadian biology
FM Hansen, MC Tanzer, F Brüning, I Bludau, C Stafford, BA Schulman, ...
Nature Communications 12 (1), 254, 2021
The brace helices of MLKL mediate interdomain communication and oligomerisation to regulate cell death by necroptosis
KA Davies, MC Tanzer, MDW Griffin, YF Mok, SN Young, R Qin, EJ Petrie, ...
Cell Death & Differentiation 25 (9), 1567-1580, 2018
The structural context of posttranslational modifications at a proteome-wide scale
I Bludau, S Willems, WF Zeng, MT Strauss, FM Hansen, MC Tanzer, ...
PLoS biology 20 (5), e3001636, 2022
A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction
JM Hildebrand, M Kauppi, IJ Majewski, Z Liu, AJ Cox, S Miyake, EJ Petrie, ...
Nature communications 11 (1), 3150, 2020
Rapid and in-depth coverage of the (phospho-) proteome with deep libraries and optimal window design for dia-PASEF
P Skowronek, M Thielert, E Voytik, MC Tanzer, FM Hansen, S Willems, ...
Molecular & Cellular Proteomics 21 (9), 2022
Quantitative and dynamic catalogs of proteins released during apoptotic and necroptotic cell death
MC Tanzer, A Frauenstein, CA Stafford, K Phulphagar, M Mann, ...
Cell reports 30 (4), 1260-1270. e5, 2020
Combination of IAP antagonist and IFNγ activates novel caspase-10-and RIPK1-dependent cell death pathways
MC Tanzer, N Khan, JA Rickard, N Etemadi, N Lalaoui, SK Spall, ...
Cell Death & Differentiation 24 (3), 481-491, 2017
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