Laura Pontano Vaites
Laura Pontano Vaites
Harvard Medical School
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The BioPlex network: a systematic exploration of the human interactome
EL Huttlin, L Ting, RJ Bruckner, F Gebreab, MP Gygi, J Szpyt, S Tam, ...
Cell 162 (2), 425-440, 2015
Architecture of the human interactome defines protein communities and disease networks
EL Huttlin, RJ Bruckner, JA Paulo, JR Cannon, L Ting, K Baltier, G Colby, ...
Nature 545 (7655), 505-509, 2017
Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss
Y Ruzankina, C Pinzon-Guzman, A Asare, T Ong, L Pontano, G Cotsarelis, ...
Cell stem cell 1 (1), 113-126, 2007
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome
EL Huttlin, RJ Bruckner, J Navarrete-Perea, JR Cannon, K Baltier, ...
Cell 184 (11), 3022-3040. e28, 2021
Excessive cell growth causes cytoplasm dilution and contributes to senescence
GE Neurohr, RL Terry, J Lengefeld, M Bonney, GP Brittingham, F Moretto, ...
cell 176 (5), 1083-1097. e18, 2019
Ferritinophagy via NCOA4 is required for erythropoiesis and is regulated by iron dependent HERC2-mediated proteolysis
JD Mancias, L Pontano Vaites, S Nissim, DE Biancur, AJ Kim, X Wang, ...
elife 4, e10308, 2015
TMTpro reagents: a set of isobaric labeling mass tags enables simultaneous proteome-wide measurements across 16 samples
J Li, JG Van Vranken, L Pontano Vaites, DK Schweppe, EL Huttlin, ...
Nature methods 17 (4), 399-404, 2020
A quantitative tissue-specific landscape of protein redox regulation during aging
H Xiao, MP Jedrychowski, DK Schweppe, EL Huttlin, Q Yu, DE Heppner, ...
Cell 180 (5), 968-983. e24, 2020
Nuclear cyclin D1/CDK4 kinase regulates CUL4 expression and triggers neoplastic growth via activation of the PRMT5 methyltransferase
P Aggarwal, LP Vaites, JK Kim, H Mellert, B Gurung, H Nakagawa, ...
Cancer cell 18 (4), 329-340, 2010
Probing the global cellular responses to lipotoxicity caused by saturated fatty acids
M Piccolis, LM Bond, M Kampmann, P Pulimeno, C Chitraju, CBK Jayson, ...
Molecular cell 74 (1), 32-44. e8, 2019
A systematic analysis of factors localized to damaged chromatin reveals PARP-dependent recruitment of transcription factors
L Izhar, B Adamson, A Ciccia, J Lewis, L Pontano-Vaites, Y Leng, ...
Cell reports 11 (9), 1486-1500, 2015
Nuclear accumulation of cyclin D1 during S phase inhibits Cul4-dependent Cdt1 proteolysis and triggers p53-dependent DNA rereplication
P Aggarwal, MD Lessie, DI Lin, L Pontano, AB Gladden, B Nuskey, ...
Genes & development 21 (22), 2908-2922, 2007
PERK utilizes intrinsic lipid kinase activity to generate phosphatidic acid, mediate Akt activation, and promote adipocyte differentiation
E Bobrovnikova-Marjon, D Pytel, MJ Riese, LP Vaites, N Singh, ...
Molecular and cellular biology 32 (12), 2268-2278, 2012
Systematic analysis of human cells lacking ATG8 proteins uncovers roles for GABARAPs and the CCZ1/MON1 regulator C18orf8/RMC1 in macroautophagic and selective autophagic flux
LP Vaites, JA Paulo, EL Huttlin, JW Harper
Molecular and cellular biology, 2018
Protein aggregation mediates stoichiometry of protein complexes in aneuploid cells
CM Brennan, LP Vaites, JN Wells, S Santaguida, JA Paulo, Z Storchova, ...
Genes & development 33 (15-16), 1031-1047, 2019
The Fbx4 tumor suppressor regulates cyclin D1 accumulation and prevents neoplastic transformation
LP Vaites, EK Lee, Z Lian, O Barbash, D Roy, M Wasik, AJP Klein-Szanto, ...
Molecular and cellular biology 31 (22), 4513-4523, 2011
Proteome-wide mapping of short-lived proteins in human cells
J Li, Z Cai, LP Vaites, N Shen, DC Mitchell, EL Huttlin, JA Paulo, BL Harry, ...
Molecular cell 81 (22), 4722-4735. e5, 2021
Genotoxic stress-induced cyclin D1 phosphorylation and proteolysis are required for genomic stability
LL Pontano, P Aggarwal, O Barbash, EJ Brown, CH Bassing, JA Diehl
Molecular and cellular biology 28 (23), 7245-7258, 2008
Hook3 is a scaffold for the opposite-polarity microtubule-based motors cytoplasmic dynein-1 and KIF1C
AA Kendrick, AM Dickey, WB Redwine, PT Tran, LP Vaites, ...
Journal of Cell Biology 218 (9), 2982-3001, 2019
A multi-scale map of cell structure fusing protein images and interactions
Y Qin, EL Huttlin, CF Winsnes, ML Gosztyla, L Wacheul, MR Kelly, ...
Nature 600 (7889), 536-542, 2021
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