James E Vince
James E Vince
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IAP antagonists target cIAP1 to induce TNFα-dependent apoptosis
JE Vince, WWL Wong, N Khan, R Feltham, D Chau, AU Ahmed, ...
Cell 131 (4), 682-693, 2007
Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction
TL Haas, CH Emmerich, B Gerlach, AC Schmukle, SM Cordier, E Rieser, ...
Molecular cell 36 (5), 831-844, 2009
Pyroptosis versus necroptosis: similarities, differences, and crosstalk
D Frank, JE Vince
Cell Death & Differentiation 26 (1), 99-114, 2019
RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL
KE Lawlor, N Khan, A Mildenhall, M Gerlic, BA Croker, AA D’Cruz, C Hall, ...
Nature communications 6 (1), 6282, 2015
RIPK1 regulates RIPK3-MLKL-driven systemic inflammation and emergency hematopoiesis
JA Rickard, JA O’Donnell, JM Evans, N Lalaoui, AR Poh, TW Rogers, ...
Cell 157 (5), 1175-1188, 2014
Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin-1 activation
JE Vince, WWL Wong, I Gentle, KE Lawlor, R Allam, L O'Reilly, K Mason, ...
Immunity 36 (2), 215-227, 2012
AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC
V Sagulenko, SJ Thygesen, DP Sester, A Idris, JA Cridland, PR Vajjhala, ...
Cell Death & Differentiation 20 (9), 1149-1160, 2013
The NLRP3 inflammasome in health and disease: the good, the bad and the ugly
P Menu, JE Vince
Clinical & Experimental Immunology 166 (1), 1-15, 2011
Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner
SA Conos, KW Chen, D De Nardo, H Hara, L Whitehead, G Núñez, ...
Proceedings of the National Academy of Sciences 114 (6), E961-E969, 2017
TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1–TRAF2 complex to sensitize tumor cells to TNFα
JE Vince, D Chau, B Callus, WWL Wong, CJ Hawkins, P Schneider, ...
The Journal of cell biology 182 (1), 171-184, 2008
TRAF2 must bind to cellular inhibitors of apoptosis for tumor necrosis factor (TNF) to efficiently activate NF-κB and to prevent TNF-induced apoptosis
JE Vince, D Pantaki, R Feltham, PD Mace, SM Cordier, AC Schmukle, ...
Journal of Biological Chemistry 284 (51), 35906-35915, 2009
Mitochondrial apoptosis is dispensable for NLRP 3 inflammasome activation but non‐apoptotic caspase‐8 is required for inflammasome priming
R Allam, KE Lawlor, ECW Yu, AL Mildenhall, DM Moujalled, RS Lewis, ...
EMBO reports 15 (9), 982-990, 2014
The pathogen Candida albicans hijacks pyroptosis for escape from macrophages
N Uwamahoro, J Verma-Gaur, HH Shen, Y Qu, R Lewis, J Lu, K Bambery, ...
MBio 5 (2), 10.1128/mbio. 00003-14, 2014
Surface determinants of Leishmania parasites and their role in infectivity in the mammalian host
T Naderer, JE Vince, MJ McConville
Current molecular medicine 4 (6), 649-665, 2004
The mitochondrial apoptotic effectors BAX/BAK activate caspase-3 and-7 to trigger NLRP3 inflammasome and caspase-8 driven IL-1β activation
JE Vince, D De Nardo, W Gao, AJ Vince, C Hall, K McArthur, D Simpson, ...
Cell reports 25 (9), 2339-2353. e4, 2018
Oxidative stress and NLRP3-inflammasome activity as significant drivers of diabetic cardiovascular complications: therapeutic implications
A Sharma, M Tate, G Mathew, JE Vince, RH Ritchie, JB De Haan
Frontiers in physiology 9, 331431, 2018
EspL is a bacterial cysteine protease effector that cleaves RHIM proteins to block necroptosis and inflammation
JS Pearson, C Giogha, S Mühlen, U Nachbur, CLL Pham, Y Zhang, ...
Nature microbiology 2 (4), 1-10, 2017
The intersection of cell death and inflammasome activation
JE Vince, J Silke
Cellular and Molecular Life Sciences 73, 2349-2367, 2016
TNF can activate RIPK3 and cause programmed necrosis in the absence of RIPK1
DM Moujalled, WD Cook, T Okamoto, J Murphy, KE Lawlor, JE Vince, ...
Cell death & disease 4 (1), e465-e465, 2013
Birinapant, a smac-mimetic with improved tolerability for the treatment of solid tumors and hematological malignancies
SM Condon, Y Mitsuuchi, Y Deng, MG LaPorte, SR Rippin, T Haimowitz, ...
Journal of medicinal chemistry 57 (9), 3666-3677, 2014
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