Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan KT Howitz, KJ Bitterman, HY Cohen, DW Lamming, S Lavu, JG Wood, ... Nature 425 (6954), 191-196, 2003 | 4909 | 2003 |
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase A Brunet, LB Sweeney, JF Sturgill, KF Chua, PL Greer, Y Lin, H Tran, ... science 303 (5666), 2011-2015, 2004 | 3842 | 2004 |
Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase HY Cohen, C Miller, KJ Bitterman, NR Wall, B Hekking, B Kessler, ... science 305 (5682), 390-392, 2004 | 2436 | 2004 |
Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1 KJ Bitterman, RM Anderson, HY Cohen, M Latorre-Esteves, DA Sinclair Journal of Biological Chemistry 277 (47), 45099-45107, 2002 | 1314 | 2002 |
The sirtuin SIRT6 regulates lifespan in male mice Y Kanfi, S Naiman, G Amir, V Peshti, G Zinman, L Nahum, Z Bar-Joseph, ... Nature 483 (7388), 218-221, 2012 | 1222 | 2012 |
Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis HY Cohen, S Lavu, KJ Bitterman, B Hekking, TA Imahiyerobo, C Miller, ... Molecular cell 13 (5), 627-638, 2004 | 745 | 2004 |
LINE1 derepression in aged wild-type and SIRT6-deficient mice drives inflammation M Simon, M Van Meter, J Ablaeva, Z Ke, RS Gonzalez, T Taguchi, ... Cell metabolism 29 (4), 871-885. e5, 2019 | 389 | 2019 |
Manipulation of a nuclear NAD+ salvage pathway delays aging without altering steady-state NAD+ levels RM Anderson, KJ Bitterman, JG Wood, O Medvedik, H Cohen, SS Lin, ... Journal of Biological Chemistry 277 (21), 18881-18890, 2002 | 379 | 2002 |
SIRT6 protects against pathological damage caused by diet‐induced obesity Y Kanfi, V Peshti, R Gil, S Naiman, L Nahum, E Levin, N Kronfeld‐Schor, ... Aging cell 9 (2), 162-173, 2010 | 359 | 2010 |
Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide K Schmeisser, J Mansfeld, D Kuhlow, S Weimer, S Priebe, I Heiland, ... Nature chemical biology 9 (11), 693-700, 2013 | 240 | 2013 |
Nicotinamide, a SIRT1 inhibitor, inhibits differentiation and facilitates expansion of hematopoietic progenitor cells with enhanced bone marrow homing and engraftment T Peled, H Shoham, D Aschengrau, D Yackoubov, G Frei, B Lerrer, ... Experimental hematology 40 (4), 342-355. e1, 2012 | 217 | 2012 |
Recombination-mediated lengthening of terminal telomeric repeats requires the Sgs1 DNA helicase H Cohen, DA Sinclair Proceedings of the National Academy of Sciences 98 (6), 3174-3179, 2001 | 206 | 2001 |
Regulation of SIRT6 protein levels by nutrient availability Y Kanfi, R Shalman, V Peshti, SN Pilosof, YM Gozlan, KJ Pearson, ... FEBS letters 582 (5), 543-548, 2008 | 201 | 2008 |
Mammalian conserved ADAR targets comprise only a small fragment of the human editosome Y Pinto, HY Cohen, EY Levanon Genome biology 15, 1-15, 2014 | 177 | 2014 |
Multiple regulatory layers of SREBP1/2 by SIRT6 S Elhanati, Y Kanfi, A Varvak, A Roichman, I Carmel-Gross, S Barth, ... Cell reports 4 (5), 905-912, 2013 | 172 | 2013 |
Regulation of SIRT1 protein levels by nutrient availability Y Kanfi, V Peshti, YM Gozlan, M Rathaus, R Gil, HY Cohen FEBS letters 582 (16), 2417-2423, 2008 | 159 | 2008 |
Restoration of energy homeostasis by SIRT6 extends healthy lifespan A Roichman, S Elhanati, MA Aon, I Abramovich, A Di Francesco, ... Nature communications 12 (1), 3208, 2021 | 144 | 2021 |
SIRT6 exhibits nucleosome-dependent deacetylase activity R Gil, S Barth, Y Kanfi, HY Cohen Nucleic acids research 41 (18), 8537-8545, 2013 | 142 | 2013 |
Regulation of the proapoptotic factor Bax by Ku70-dependent deubiquitylation AD Amsel, M Rathaus, N Kronman, HY Cohen Proceedings of the National Academy of Sciences 105 (13), 5117-5122, 2008 | 129 | 2008 |
Bax-inhibiting peptide protects cells from polyglutamine toxicity caused by Ku70 acetylation Y Li, T Yokota, V Gama, T Yoshida, JA Gomez, K Ishikawa, H Sasaguri, ... Cell Death & Differentiation 14 (12), 2058-2067, 2007 | 114 | 2007 |