Defining network topologies that can achieve biochemical adaptation W Ma, A Trusina, H El-Samad, WA Lim, C Tang Cell 138 (4), 760-773, 2009 | 1082 | 2009 |
Conformational biosensors reveal GPCR signalling from endosomes R Irannejad, JC Tomshine, JR Tomshine, M Chevalier, JP Mahoney, ... Nature 495 (7442), 534-538, 2013 | 883 | 2013 |
BiP binding to the ER-stress sensor Ire1 tunes the homeostatic behavior of the unfolded protein response D Pincus, MW Chevalier, T Aragón, E van Anken, SE Vidal, H El-Samad, ... PLoS biology 8 (7), e1000415, 2010 | 519 | 2010 |
Surviving heat shock: control strategies for robustness and performance H El-Samad, H Kurata, JC Doyle, CA Gross, M Khammash Proceedings of the National Academy of Sciences 102 (8), 2736-2741, 2005 | 341 | 2005 |
In silico feedback for in vivo regulation of a gene expression circuit A Milias-Argeitis, S Summers, J Stewart-Ornstein, I Zuleta, D Pincus, ... Nature biotechnology 29 (12), 1114-1116, 2011 | 338 | 2011 |
De novo design of bioactive protein switches RA Langan, SE Boyken, AH Ng, JA Samson, G Dods, AM Westbrook, ... Nature 572 (7768), 205-210, 2019 | 280 | 2019 |
Calcium homeostasis and parturient hypocalcemia: an integral feedback perspective H El-Samad, JP Goff, M Khammash Journal of theoretical biology 214 (1), 17-29, 2002 | 250 | 2002 |
De novo design of protein logic gates Z Chen, RD Kibler, A Hunt, F Busch, J Pearl, M Jia, ZL VanAernum, ... Science 368 (6486), 78-84, 2020 | 216 | 2020 |
Stochastic modelling of gene regulatory networks H El Samad, M Khammash, L Petzold, D Gillespie International Journal of Robust and Nonlinear Control: IFAC‐Affiliated …, 2005 | 209 | 2005 |
Low dimensionality in gene expression data enables the accurate extraction of transcriptional programs from shallow sequencing G Heimberg, R Bhatnagar, H El-Samad, M Thomson Cell systems 2 (4), 239-250, 2016 | 194 | 2016 |
Cellular noise regulons underlie fluctuations in Saccharomyces cerevisiae J Stewart-Ornstein, JS Weissman, H El-Samad Molecular cell 45 (4), 483-493, 2012 | 193 | 2012 |
Controlling CRISPR-Cas9 with ligand-activated and ligand-deactivated sgRNAs K Kundert, JE Lucas, KE Watters, C Fellmann, AH Ng, BM Heineike, ... Nature communications 10 (1), 2127, 2019 | 188 | 2019 |
Homeostatic adaptation to endoplasmic reticulum stress depends on Ire1 kinase activity C Rubio, D Pincus, A Korennykh, S Schuck, H El-Samad, P Walter Journal of Cell Biology 193 (1), 171-184, 2011 | 186 | 2011 |
Fund black scientists KR Stevens, KS Masters, PI Imoukhuede, KA Haynes, LA Setton, ... Cell 184 (3), 561-565, 2021 | 142 | 2021 |
Module-based analysis of robustness tradeoffs in the heat shock response system H Kurata, H El-Samad, R Iwasaki, H Ohtake, JC Doyle, I Grigorova, ... PLoS computational biology 2 (7), e59, 2006 | 135 | 2006 |
Bound attractant at the leading vs. the trailing edge determines chemotactic prowess P Herzmark, K Campbell, F Wang, K Wong, H El-Samad, A Groisman, ... Proceedings of the National Academy of Sciences 104 (33), 13349-13354, 2007 | 124 | 2007 |
Synthetic cytokine circuits that drive T cells into immune-excluded tumors GM Allen, NW Frankel, NR Reddy, HK Bhargava, MA Yoshida, SR Stark, ... Science 378 (6625), eaba1624, 2022 | 123 | 2022 |
Population diversification in a yeast metabolic program promotes anticipation of environmental shifts OS Venturelli, I Zuleta, RM Murray, H El-Samad PLoS biology 13 (1), e1002042, 2015 | 123 | 2015 |
Modular and tunable biological feedback control using a de novo protein switch AH Ng, TH Nguyen, M Gómez-Schiavon, G Dods, RA Langan, SE Boyken, ... Nature 572 (7768), 265-269, 2019 | 120 | 2019 |
Design and analysis of a proportional-integral-derivative controller with biological molecules M Chevalier, M Gómez-Schiavon, AH Ng, H El-Samad Cell systems 9 (4), 338-353. e10, 2019 | 107 | 2019 |