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Matthew Ling-Hon Chu
Matthew Ling-Hon Chu
Astellas Pharma US
Dirección de correo verificada de astellas.com - Página principal
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Cryo-EM structure of the activated GLP-1 receptor in complex with a G protein
Y Zhang, B Sun, D Feng, H Hu, M Chu, Q Qu, JT Tarrasch, S Li, ...
Nature 546 (7657), 248-253, 2017
5372017
Structural insights into the activation of metabotropic glutamate receptors
A Koehl, H Hu, D Feng, B Sun, Y Zhang, MJ Robertson, M Chu, ...
Nature 566 (7742), 79-84, 2019
2732019
Structural basis of Wnt signaling inhibition by Dickkopf binding to LRP5/6
VE Ahn, MLH Chu, HJ Choi, D Tran, A Abo, WI Weis
Developmental cell 21 (5), 862-873, 2011
2042011
Structural basis of GSK-3 inhibition by N-terminal phosphorylation and by the Wnt receptor LRP6
JL Stamos, MLH Chu, MD Enos, N Shah, WI Weis
Elife 3, e01998, 2014
1882014
Crystal structure of the adenosine A2A receptor bound to an antagonist reveals a potential allosteric pocket
B Sun, P Bachhawat, MLH Chu, M Wood, T Ceska, ZA Sands, J Mercier, ...
Proceedings of the National Academy of Sciences 114 (8), 2066-2071, 2017
1392017
Drug-resistant aurora A mutants for cellular target validation of the small molecule kinase inhibitors MLN8054 and MLN8237
DA Sloane, MZ Trikic, MLH Chu, MBAC Lamers, CS Mason, I Mueller, ...
ACS chemical biology 5 (6), 563-576, 2010
1232010
Structural studies of Wnts and identification of an LRP6 binding site
MLH Chu, VE Ahn, HJ Choi, DL Daniels, R Nusse, WI Weis
Structure 21 (7), 1235-1242, 2013
842013
Discovery and exploitation of inhibitor-resistant aurora and polo kinase mutants for the analysis of mitotic networks
PJ Scutt, MLH Chu, DA Sloane, M Cherry, CR Bignell, DH Williams, ...
Journal of biological chemistry 284 (23), 15880-15893, 2009
802009
Crystal structure of the catalytic domain of the mitotic checkpoint kinase Mps1 in complex with SP600125
MLH Chu, LMG Chavas, KT Douglas, PA Eyers, L Tabernero
Journal of biological chemistry 283 (31), 21495-21500, 2008
662008
Phosphoregulation of human Mps1 kinase
RK Tyler, MLH Chu, H Johnson, EA McKenzie, SJ Gaskell, PA Eyers
Biochemical Journal 417 (1), 173-184, 2009
622009
Crystal structure of dopamine D1 receptor in complex with G protein and a non-catechol agonist
B Sun, D Feng, MLH Chu, I Fish, S Lovera, ZA Sands, S Kelm, A Valade, ...
Nature communications 12 (1), 3305, 2021
412021
An engineered IL15 cytokine mutein fused to an anti-PD1 improves intratumoral T-cell function and antitumor immunity
Y Xu, LC Carrascosa, YA Yeung, MLH Chu, W Yang, I Djuretic, ...
Cancer immunology research 9 (10), 1141-1157, 2021
402021
Biophysical and X-ray Crystallographic Analysis of Mps1 Kinase Inhibitor Complexes,
MLH Chu, Z Lang, LMG Chavas, J Neres, OS Fedorova, L Tabernero, ...
Biochemistry 49 (8), 1689-1701, 2010
352010
One size does not fit all: navigating the multi-dimensional space to optimize T-cell engaging protein therapeutics
W Chen, F Yang, C Wang, J Narula, E Pascua, I Ni, S Ding, X Deng, ...
MAbs 13 (1), 1871171, 2021
342021
Fusion core structure of the severe acute respiratory syndrome coronavirus (SARS‐CoV): In search of potent SARS‐CoV entry inhibitors
LHM Chu, SH Chan, SN Tsai, Y Wang, CHK Cheng, KB Wong, ...
Journal of cellular biochemistry 104 (6), 2335-2347, 2008
292008
Ligand-blocking and membrane-proximal domain targeting anti-OX40 antibodies mediate potent T cell-stimulatory and anti-tumor activity
P Zhang, GH Tu, J Wei, P Santiago, LR Larrabee, S Liao-Chan, T Mistry, ...
Cell Reports 27 (11), 3117-3123. e5, 2019
192019
Rapid peptide‐based screening on the substrate specificity of severe acute respiratory syndrome (SARS) coronavirus 3C‐like protease by matrix‐assisted laser desorption …
LHM Chu, WY Choy, SN Tsai, Z Rao, SM Ngai
Protein science 15 (4), 699-709, 2006
152006
The Lick Observatory Supernova Search follow-up program: photometry data release of 70 SESNe
WK Zheng, BE Stahl, T De Jaeger, AV Filippenko, SQ Wang, WP Gan, ...
Monthly Notices of the Royal Astronomical Society 512 (3), 3195-3214, 2022
112022
An engineered IL15 cytokine mutein fused to an anti-PD1 improves intratumoral T-cell function and antitumor immunity. Cancer Immunol. Res. 2021; 9: 1141–1157. doi: 10.1158/2326 …
Y Xu, LC Carrascosa, YA Yeung, ML Chu, W Yang, I Djuretic, DC Pappas, ...
CIR-21-0058.[Abstract][CrossRef][Google Scholar], 0
7
Structural insights into metabotropic glutamate receptor activation
A Koehl, H Hu, D Feng, B Sun, Y Zhang, MJ Robertson, M Chu, ...
Nature 566 (7742), 79, 2019
22019
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Artículos 1–20