Zhen Song
Zhen Song
Peng Cheng Laboratory
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Calcium-voltage coupling in the genesis of early and delayed afterdepolarizations in cardiac myocytes
Z Song, CY Ko, M Nivala, JN Weiss, Z Qu
Biophysical journal 108 (8), 1908-1921, 2015
Molecular basis of hypokalemia-induced ventricular fibrillation
A Pezhouman, N Singh, Z Song, M Nivala, A Eskandari, H Cao, A Bapat, ...
Circulation 132 (16), 1528-1537, 2015
General Principles for the Validation of Proarrhythmia Risk Prediction Models: An Extension of the CiPA In Silico Strategy
Z Li, GR Mirams, T Yoshinaga, BJ Ridder, X Han, JE Chen, ...
Clinical Pharmacology & Therapeutics 107 (1), 102-111, 2020
T-tubule disruption promotes calcium alternans in failing ventricular myocytes: mechanistic insights from computational modeling
M Nivala, Z Song, JN Weiss, Z Qu
Journal of molecular and cellular cardiology 79, 32-41, 2015
Mitochondrial Ca2+ influx contributes to arrhythmic risk in nonischemic cardiomyopathy
A Xie, Z Song, H Liu, A Zhou, G Shi, LH Xie, Z Qu, SC Dudley
Biophysical Journal 114 (3), 657a, 2018
New experimental evidence for mechanism of arrhythmogenic membrane potential alternans based on balance of electrogenic INCX/ICa currents
X Wan, M Cutler, Z Song, A Karma, T Matsuda, A Baba, DS Rosenbaum
Heart Rhythm 9 (10), 1698-1705, 2012
Transverse tubular network structures in the genesis of intracellular calcium alternans and triggered activity in cardiac cells
Z Song, MB Liu, Z Qu
Journal of molecular and cellular cardiology 114, 288-299, 2018
Determinants of early afterdepolarization properties in ventricular myocyte models
X Huang, Z Song, Z Qu
PLoS computational biology 14 (11), e1006382, 2018
Stochastic initiation and termination of calciummediated triggered activity in cardiac myocytes
Z Song, Z Qu, A Karma
Proceedings of the National Academy of Sciences, 2017
Long-lasting sparks: Multi-metastability and release competition in the calcium release unit network
Z Song, A Karma, JN Weiss, Z Qu
PLoS computational biology 12 (1), e1004671, 2016
Spatially Discordant Alternans and Arrhythmias in Tachypacing-Induced Cardiac Myopathy in Transgenic LQT1 Rabbits: The Importance of IKs and Ca2+ Cycling
E Lau, K Kossidas, TY Kim, Y Kunitomo, O Ziv, S Zhen, C Taylor, ...
PLoS One 10 (5), e0122754, 2015
A Dynamical Threshold for Cardiac Delayed Afterdepolarization-Mediated Triggered Activity
MB Liu, CY Ko, Z Song, A Garfinkel, JN Weiss, Z Qu
Biophysical Journal 111 (11), 2523-2533, 2016
Multiscale determinants of delayed afterdepolarization amplitude in cardiac tissue
CY Ko, MB Liu, Z Song, Z Qu, JN Weiss
Biophysical Journal 112 (9), 1949-1961, 2017
Acute reversal of phospholamban inhibition facilitates the rhythmic whole-cell propagating calcium waves in isolated ventricular myocytes
YH Chan, WC Tsai, Z Song, CY Ko, Z Qu, JN Weiss, SF Lin, PS Chen, ...
Journal of Molecular and Cellular Cardiology 80, 126-135, 2015
Mechanisms of arrhythmogenicity of hypertrophic cardiomyopathy-associated troponin T (TNNT2) variant I79N
S Shafaattalab, AY Li, MG Gunawan, BR Kim, F Jayousi, Y Maaref, ...
Frontiers in cell and developmental biology 9, 787581, 2021
Mechanisms of premature ventricular complexes caused by QT prolongation
Z Zhang, MB Liu, X Huang, Z Song, Z Qu
Biophysical journal 120 (2), 352-369, 2021
Spatially discordant repolarization alternans in the absence of conduction velocity restitution
C Huang, Z Song, J Landaw, Z Qu
Biophysical journal 118 (10), 2574-2587, 2020
A spatiotemporal ventricular myocyte model incorporating mitochondrial calcium cycling
Z Song, LH Xie, JN Weiss, Z Qu
Biophysical journal 117 (12), 2349-2360, 2019
Fibroblasts in heart scar tissue directly regulate cardiac excitability and arrhythmogenesis
Y Wang, Q Li, B Tao, M Angelini, S Ramadoss, B Sun, P Wang, ...
Science 381 (6665), 1480-1487, 2023
Small-conductance Ca2+-activated K+ channels promote J-wave syndrome and phase 2 reentry
J Landaw, Z Zhang, Z Song, MB Liu, R Olcese, PS Chen, JN Weiss, Z Qu
Heart rhythm 17 (9), 1582-1590, 2020
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