| An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor X Zhang, J Gureasko, K Shen, PA Cole, J Kuriyan Cell 125 (6), 1137-1149, 2006 | 1862 | 2006 |
| A Src-like inactive conformation in the abl tyrosine kinase domain NM Levinson, O Kuchment, K Shen, MA Young, M Koldobskiy, M Karplus, ... PLoS biology 4 (5), e144, 2006 | 354 | 2006 |
| Acquisition of a specific and potent PTP1B inhibitor from a novel combinatorial library and screening procedure K Shen, YF Keng, L Wu, XL Guo, DS Lawrence, ZY Zhang Journal of Biological Chemistry 276 (50), 47311-47319, 2001 | 286 | 2001 |
| The role of C-terminal tyrosine phosphorylation in the regulation of SHP-1 explored via expressed protein ligation Z Zhang, K Shen, W Lu, PA Cole Journal of Biological Chemistry 278 (7), 4668-4674, 2003 | 189 | 2003 |
| Crystal structure of PTP1B complexed with a potent and selective bidentate inhibitor JP Sun, AA Fedorov, SY Lee, XL Guo, K Shen, DS Lawrence, SC Almo, ... Journal of Biological Chemistry 278 (14), 12406-12414, 2003 | 183 | 2003 |
| Cellular effects of small molecule PTP1B inhibitors on insulin signaling L Xie, SY Lee, JN Andersen, S Waters, K Shen, XL Guo, NPH Moller, ... Biochemistry 42 (44), 12792-12804, 2003 | 160 | 2003 |
| Multiple regions of MAP kinase phosphatase 3 are involved in its recognition and activation by ERK2 B Zhou, L Wu, K Shen, J Zhang, DS Lawrence, ZY Zhang Journal of Biological Chemistry 276 (9), 6506-6515, 2001 | 150 | 2001 |
| Protein tyrosine kinases Src and Csk: a tail’s tale PA Cole, K Shen, Y Qiao, D Wang Current opinion in chemical biology 7 (5), 580-585, 2003 | 126 | 2003 |
| The role of the phospho-CDK2/cyclin A recruitment site in substrate recognition KY Cheng, MEM Noble, V Skamnaki, NR Brown, ED Lowe, ... Journal of Biological Chemistry 281 (32), 23167-23179, 2006 | 113 | 2006 |
| Potent and highly selective inhibitors of the protein tyrosine phosphatase 1B M Taing, YF Keng, K Shen, L Wu, DS Lawrence, ZY Zhang Biochemistry 38 (12), 3793-3803, 1999 | 101 | 1999 |
| Probing the molecular basis for potent and selective protein-tyrosine phosphatase 1B inhibition XL Guo, K Shen, F Wang, DS Lawrence, ZY Zhang Journal of Biological Chemistry 277 (43), 41014-41022, 2002 | 92 | 2002 |
| Protein kinase structure and function analysis with chemical tools K Shen, AC Hines, D Schwarzer, KA Pickin, PA Cole Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1754 (1-2), 65-78, 2005 | 89 | 2005 |
| Chemical dissection of the effects of tyrosine phosphorylation of SHP-2 W Lu, K Shen, PA Cole Biochemistry 42 (18), 5461-5468, 2003 | 77 | 2003 |
| PRL-1 protein promotes ERK1/2 and RhoA protein activation through a non-canonical interaction with the Src homology 3 domain of p115 Rho GTPase-activating protein Y Bai, Y Luo, S Liu, L Zhang, K Shen, Y Dong, CD Walls, LA Quilliam, ... Journal of Biological Chemistry 286 (49), 42316-42324, 2011 | 53 | 2011 |
| Conversion of a tyrosine kinase protein substrate to a high affinity ligand by ATP linkage K Shen, PA Cole Journal of the American Chemical Society 125 (52), 16172-16173, 2003 | 46 | 2003 |
| A molecular mechanism for IL-4 suppression of loricrin transcription in epidermal keratinocytes: implication for atopic dermatitis pathogenesis L Bao, GC Mohan, JB Alexander, C Doo, K Shen, J Bao, LS Chan Innate immunity 23 (8), 641-647, 2017 | 44 | 2017 |
| Tumor suppressor PRSS8 targets Sphk1/S1P/Stat3/Akt signaling in colorectal cancer Y Bao, K Li, Y Guo, Q Wang, Z Li, Y Yang, Z Chen, J Wang, W Zhang, ... Oncotarget, 2016 | 41 | 2016 |
| Chemical approaches to reversible protein phosphorylation PA Cole, AD Courtney, K Shen, Z Zhang, Y Qiao, W Lu, DM Williams Accounts of chemical research 36 (6), 444-452, 2003 | 41 | 2003 |
| Multilayered coatings for protecting carbon-carbon composites from oxidation M Guo, K Shen, Y Zheng Carbon 33 (4), 449-453, 1995 | 28 | 1995 |
| Interleukin-4 Downregulation of Involucrin Expression in Human Epidermal Keratinocytes Involves Stat6 Sequestration of the Coactivator CREB-Binding Protein L Bao, JB Alexander, H Zhang, K Shen, LS Chan Journal of Interferon & Cytokine Research 36 (6), 374-381, 2016 | 25 | 2016 |
